This federal Project Grant award for $169,000.00, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports the development of a single-cell reference atlas of axolotl embryogenesis. The overarching goal is to elucidate the fundamental biological processes required for limb regeneration, with the aim of informing future regenerative medicine strategies for human limb injuries...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $224,648 to the University of California, Irvine to conduct collaborative research on the shared genetic and cellular mechanisms underlying vertebrate limb and fin regeneration. The research aims to identify the core components of a "toolkit" for limb and fin regeneration by studying the axolotl, African lungfish, and grey bichir. Key objectives include: 1) Testing the...
This Project Grant award of $251,118.00 from the National Science Foundation (NSF) Biological Sciences (CFDA 47.074) Federal Grant Program supports a collaborative research project to investigate the shared genetic and cellular mechanisms underlying limb and fin regeneration in vertebrates. The key objectives of the research are to: 1) test whether rapid activation of the mTOR signaling pathway is a conserved feature of limb and fin regeneration, 2) use transcriptomic and epigenetic profiling to...
This $1,174,440.00 federal Project Grant award, funded by the National Science Foundation (NSF) Division of Integrative Organismal Systems (CFDA 47.074 Biological Sciences), supports collaborative research to identify the shared genetic and cellular mechanisms underlying vertebrate limb and fin regeneration. The research team at Louisiana State University, the prime awardee, is using a comparative approach across three animal models - salamanders, lungfish, and Polypterus - to uncover the core...
The federal Project Grant award R21HD116006 for $270,000.00, awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will fund research to elucidate the cellular and molecular mechanisms enabling spinal cord regeneration in zebrafish. The primary objectives are to: 1) Analyze cell state changes over time associated with successful versus failed spinal cord...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), provides $485,782 to Texas A&M AgriLife Research to conduct research on the role of mechanical load in mammalian digit regeneration. The key objectives of this 5-year award, with a start date of June 1, 2025 and completion date of February 28, 2030, are to: 1) determine the...
This federal Project Grant award of $294,408, provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the role of Sonic Hedgehog signaling in regulating skeletal patterning during zebrafish fin regeneration. The research aims to identify key Sonic Hedgehog target genes and how they facilitate interactions between Sonic...
The National Institute of Child Health and Human Development (NICHD) awarded a $136,916 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the Louisiana State University Agricultural Center to develop a computational model for predicting the morphology, patterning, and strength of regenerated bone in small animal models of limb regeneration. The project aims to create new tools to better evaluate the structural quality and function of regenerated bone,...
This federal Project Grant award, with ID K99HD119028, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $114,458 award, with a performance period from August 1, 2025 to July 31, 2027, will support research at Duke University to quantitatively investigate how zebrafish appendage regeneration encodes and processes size memory at the cellular...
This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to investigate the role of macrophages in guiding bone and soft tissue regeneration after amputation in mice. The $687,427 award, spanning Aug 1, 2025 to Apr 30, 2030, will fund research at the University of Kentucky Research Foundation to: Test if the unique metabolic and signaling profile of macrophages...