Project Grant R01HD114720

Award Date 7/1/24
Completion Date 4/30/29
Dollars Obligated $1.8M
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
La Jolla, CA 92093, USA
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This Project Grant award of $191,965.00 from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to elucidate the upstream transcription factors controlling preeclampsia-specific gene expression using human trophoblast stem cells as a model system. The key objectives are to 1) identify and functionally validate putative preeclampsia-driver transcription factors that can induce preeclampsia-specific gene...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support the development of a microfluidic human placenta organoid model at Syracuse University. The $411,125 award will fund research to derive human trophoblast stem cells from induced pluripotent stem cells and use them to generate placental organoids that can recapitulate early-to-mid gestation...
This National Science Foundation (NSF) Engineering (CFDA 47.041) Project Grant award to Worcester Polytechnic Institute (WPI) in the amount of $259,570 will develop 3D spheroid models using patient-derived trophoblast cells to investigate placental cell invasion and study preeclampsia, a pregnancy complication with high global maternal and infant mortality rates. The 2-year project will design culture conditions to maintain the spheroid models, engineer an extracellular matrix to mimic the...
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This $293,756 federal Project Grant (R21HD112819) was awarded on July 11, 2024 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to enhance understanding of the molecular mechanisms underlying placental dysfunction in common obstetric disorders such as preeclampsia, preterm birth, and fetal growth restriction. The research, led by the Institute for Systems...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $456,251 to Colorado State University from August 1, 2024 to May 31, 2029 to conduct research on the mechanisms linking maternal obesity and inflammation to abnormal placental development and preeclampsia. The overarching goal is to test the hypothesis that pro-inflammatory mediators produced by...
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This $148,880 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research on the role of B cells and autoantibodies in preeclampsia and their long-term effects on the offspring. The research aims to: Test the hypothesis that B cells from women with preeclampsia produce autoantibodies that cause hypertension, cerebrovascular dysfunction, and cognitive...
The National Institute of Child Health and Human Development (NICHD) awarded Cedars-Sinai Medical Center a $250,500 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to conduct research on the role of L-kynurenine deficiency in the pathogenesis of preeclampsia in animal models of impaired renal reserve. The research aims to improve methods for diagnosing and monitoring preeclampsia in high-risk populations, as well as develop targeted, pathophysiology-based...
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