This $704,154 Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the impact of maternal obesity and diet on embryo and fetal DNA methylation programming. The award recipient, Oregon Health & Science University (OHSU), will assess alterations in DNA methylation, gene expression, and chromosome fidelity in preimplantation embryos from female rhesus macaques fed a high-fat Western-style diet. The project will also evaluate how maternal diet and metabolism influence DNA methylation and gene expression across fetal tissues like the thymus, spleen, liver, and kidney. By comparing these epigenetic changes in embryos and fetuses, the study aims to identify genomic regions susceptible to adverse metabolic conditions during development. Findings from this 5-year project could provide insights into the developmental reprogramming and reproductive consequences of stable DNA methylation changes induced by maternal obesity and diet.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $704.2k | 9/13/24 |