Project Grant R01HD113280
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is focused on elucidating the role of the TMC5 gene in the process of spermiogenesis, which is critical for male fertility. The $484,967 award to the University of Virginia will support a multi-scale research approach to investigate the molecular function of TMC5 and its specific role in...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $152,834 to the University of Toledo to study the composition of sperm striated columns and their role in sperm movement and zygote centrosome function. The goal is to identify biomarkers of the striated columns to enable future research on their contributions to male infertility...
- This federal Project Grant award of $128,898 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to elucidate how the 3D genome regulates the transcriptional program during mouse spermatogenesis, with the goal of providing insight into how male germ cell identity is established. The principal investigator will perform high-resolution Hi-C analysis...
- The federal Project Grant award titled "MECHANISMS OF DOUBLE STRAND BREAK REPAIR IN FETAL MALE GERM CELLS" was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $107,458 award, granted on May 1, 2025, supports research at Duke University to determine how male germ cells in the fetal stage repair double-strand DNA breaks and maintain genomic...
- This Project Grant award, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Federal Grant Program (CFDA 93.865), supports research to elucidate the patterns and transmission of de novo mutations in human sperm. The $249,000 award, with a performance period from July 1, 2025 to July 31, 2028, will enable the University of Utah to conduct a study comparing the genomic sequences of...
- The National Institute of Child Health and Human Development (NICHD) awarded Yale University a $921,250 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant funds a 2-year project to define the molecular pathways governing chromocenter restructuring before and after fertilization. The study aims to determine how the chromatin regulator DOT1L controls chromocenter disassembly during sperm nuclear condensation, as well as how DOT1L...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $746,999 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Broad Institute, Inc. to characterize the genetic etiology of delayed puberty and rare congenital forms of infertility. The research project aims to: 1) Define the spectrum of genomic variants contributing to idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome...
- This federal Project Grant award of $108,512 from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to investigate the mechanisms by which the salt-inducible kinase 3 (SIK3) regulates fertility and ovarian granulosa cell function. The research focuses on elucidating SIK3's upstream regulation, downstream targets, and role in metabolism during follicle development and granulosa cell...
- The University of Utah was awarded a $227,449 Project Grant by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) on December 31, 2024. The grant supports research to lineage trace the contributions of individual spermatogonial stem cells (SSCs) to sperm production across the fertile lifespan of male zebrafish. The central hypothesis is that SSCs compete for dominance and that paternal age...
- This $616,841 project grant was awarded by the National Institute of Child Health and Human Development (NICHD), under the CFDA program "Child Health and Human Development Extramural Research", to Yale University beginning on August 15, 2025 and scheduled for completion on April 30, 2030. The project aims to investigate the molecular mechanisms that regulate genome activation and gene expression during embryonic development in vertebrates, with a focus on understanding how specific...
The federal Project Grant award of $561,097 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research by Yale University to investigate the genetic basis and molecular mechanisms underlying reduced sperm motility, a leading cause of male infertility. The research aims to capitalize on the university's access to large consanguineous Pakistani families with abnormal semen parameters, as well as its expertise in mouse genetics, proteogenomics, and advanced imaging techniques like cryo-electron tomography. The goal is to break new ground in understanding the genetic factors and cellular processes contributing to reduced sperm motility, which affects approximately 80% of infertile male patients, in order to aid the development of potential treatments. The award period runs from August 8, 2025 to April 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $561.1k | 8/7/25 |