Project Grant R00HD107222
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $352,674 to The Research Foundation for the State University of New York (RF-SUNY) at the University at Albany to conduct research on the molecular mechanisms underlying terminal nerve development, GnRH-1 neuronal migration, and olfactory bulb formation in normal and pathological...
- This federal Project Grant award of $128,898 was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to elucidate how the 3D genome regulates the transcriptional program during mouse spermatogenesis, with the goal of providing insight into how male germ cell identity is established. The principal investigator will perform high-resolution Hi-C analysis...
- The federal Project Grant award of $561,097 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research by Yale University to investigate the genetic basis and molecular mechanisms underlying reduced sperm motility, a leading cause of male infertility. The research aims to capitalize on the university's access to large consanguineous Pakistani families with abnormal semen...
- The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $606,518 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Magee-Womens Research Institute and Foundation. The grant, awarded on June 5, 2025, supports research to develop and test the safety and feasibility of spermatogonial stem cell (SSC) transplantation and testicular tissue grafting techniques for restoring fertility in patients,...
- This Project Grant award, totaling $419,014, was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to investigate the role of the transcription factor SOX9 in regulating the ovulatory process and corpus luteum development in the human ovary. The research aims to provide critical insights into the mechanisms underlying...
- This Project Grant award of $170,640 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) aims to investigate the role of the FGFR1 signaling pathway in the intersection between reproduction and metabolism. The primary objectives of this 5-year research project are to: (1) conduct a recall-by-genotype study and in-depth neuroendocrine and metabolic phenotyping in...
- The federal Project Grant award titled "MECHANISMS OF DOUBLE STRAND BREAK REPAIR IN FETAL MALE GERM CELLS" was provided by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The $107,458 award, granted on May 1, 2025, supports research at Duke University to determine how male germ cells in the fetal stage repair double-strand DNA breaks and maintain genomic...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is focused on identifying novel noncoding genetic mechanisms that contribute to developmental disorders. The $499,055.48 award, with a project period from November 1, 2024 to October 31, 2027, will fund research led by Dr. Chelsea Lowther at the Icahn School of Medicine at Mount...
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to functionally and architecturally characterize the role of RFamide-related peptide (RFRP) neurons in controlling the timing of puberty onset. The $126,462 award to the University of California, San Diego will leverage state-of-the-art molecular genetic tools to delineate...
- This federal Project Grant award of $624,809.00, funded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research Program (CFDA 93.865), supports research on the dopaminergic regulation of KNDY neurons and its implications for GnRH pulses and polycystic ovary syndrome (PCOS). The project, led by Brigham & Women's Hospital Inc. and involving the larger Partners Healthcare System (now Mass...
The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) awarded a $746,999 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Broad Institute, Inc. to characterize the genetic etiology of delayed puberty and rare congenital forms of infertility. The research project aims to: 1) Define the spectrum of genomic variants contributing to idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS) through whole genome sequencing of the largest global cohort of these patients; 2) Examine the impact of loss-of-function mutations in infertility genes on transcriptome dysregulation in gonadotropin-releasing hormone (GnRH) neurons; and 3) Investigate the effects of genetic variants on constitutional delayed puberty in a broader population. The project will leverage statistical modeling, transcriptome analysis, and interpretation of genomic data to gain insights into the genetic underpinnings of rare forms of infertility. The award period runs from July 2025 through June 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $747.0k | 7/23/25 |