Project Grant R00HD111686
- This federal Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $107,458 to Duke University to research the mechanisms of double-strand DNA break repair in fetal male germ cells. The overarching objective is to determine how male germ cells respond to and repair double-strand DNA breaks during a critical period of quiescence prior to...
- This $1,122,194 federal Project Grant award, funded by the National Institute of Child Health and Human Development (NICHD) through the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to understand the genetic basis and cellular/molecular mechanisms underlying reduced sperm motility, a key factor in male infertility. The award recipient, Yale University, will leverage access to 16 large consanguineous Pakistani families with abnormal semen...
- This federal Project Grant award of $128,898 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research into how the 3D structure of the genome regulates gene expression during male germ cell development and spermatogenesis. The research aims to elucidate how the 3D chromatin structure and CTCF-mediated genome organization in male germ cells establishes...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $152,834 to the University of Toledo to study the composition of sperm striated columns and their role in sperm movement and zygote centrosome function. The goal is to identify biomarkers of the striated columns to enable future research on their contributions to male infertility...
- This $497,689 Project Grant was awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to investigate the role of actin, a key structural protein, in ensuring accurate chromosome segregation and mitotic fidelity during early mammalian embryo development. The research aims to determine how nuclear actin cables and peri-spindle actin...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $148,000.00 to the University of Southern Mississippi to investigate the potential molecular mechanisms linking infertility and cancer. The primary objectives are to (1) use humanized yeast to assess the impact of 30 cancer-associated protein phosphatase 1 (PP1) variants on...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $151,040 to support research on the regulation of spermiogenesis (sperm development) by the proteins Combover (CMB) and Mindbomb 2 (MIB2). The research, conducted by the Albert Einstein College of Medicine in Bronx, NY, aims to investigate how MIB2, an E3 ubiquitin ligase, may...
- This Project Grant award from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research on the dynamics of developmental defect formation. The $133,588 award to The Trustees of Princeton University will utilize live imaging approaches in a Drosophila model system to identify the point in development most vulnerable to the effects of mutations linked...
- This federal Project Grant award of $484,967 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports research to elucidate the function of the novel gene TMC5 and its role in spermiogenesis, the final stage of sperm development. The research team at the University of Virginia is utilizing a multi-scale approach, including developing genetically engineered mouse models and...
- The University of California, San Francisco (UCSF) was awarded a $168,954 project grant from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), as part of the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant, awarded on May 27, 2025, will fund research to "Quantify Germ Cell Lineage Dynamics in Mammalian Oogenesis." The project aims to characterize the selection and functional importance of early...
This Project Grant, awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $249,000 in funding to the University of Utah from July 2025 to July 2028. The project aims to unravel the features of non-clonal gonadal mutation burdens at the single-cell level through experimental and computational approaches. Specifically, the research will analyze the genomic sequences of 700 single human sperm from 35 healthy young men to understand how paternal-specific clonal and non-clonal mosaicism contribute to genetic variability across human generations and the transmission of de novo mutations to offspring. This work builds on the principal investigator's prior research establishing the concept that a significant portion of de novo mutations in children with neurological and psychiatric disorders arise from clonal mosaic mutations in sperm.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/14/25 |