Project Grant R21HD114044
Award Date
9/20/23
Completion Date
8/31/25
Dollars Obligated
$414K
Federal Agency
National Institute of Child Health and Human Development
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Penn State University, PA 16802, USA
Similar Awards
The National Institute of Child Health and Human Development (NICHD) awarded a $606,518 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the Magee-Womens Research Institute and Foundation in Pittsburgh, Pennsylvania. The grant funding supports research to develop and test methods for transplanting spermatogonial stem cells (SSCs) and testicular tissue grafts to restore fertility in male cancer survivors who previously had their immature testicular tissue...
The National Institute of Child Health and Human Development (NICHD) awarded The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, a $162,500 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) on September 22, 2023. The grant supports the development of tools to visualize the construction and assembly of the Posterior Signaling Center (PSC), a cell niche that controls the progenitors of insect...
This federal Project Grant award of $2,228,898 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports the development of a microwell device and deep learning framework to enable accurate, reliable, and consistent sperm identification and retrieval. The award aims to address the challenges faced by individuals with azoospermia, a condition where semen lacks sperm, which impacts up to...
This federal Project Grant award of $243,750 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research on the maternal regulation of microtubules in egg developmental competency. The research, conducted by the Trustees of the University of Pennsylvania, investigates the dynamics, etiology, and nature of spindle-like microtubule structures and vesicle-like structures observed...
This Project Grant award, totaling $658,633, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support research into the mechanisms of the MEIG1 protein complex in mammalian spermiogenesis and fertilization. The research aims to explore how the MEIG1 complex plays a role in transporting cargo proteins for sperm flagella assembly and in remodeling chromatin during the final...
The National Institute of Child Health and Human Development (NICHD) awarded a $192,056 Project Grant (CFDA 93.865) to the Magee-Womens Research Institute and Foundation to develop an adeno-associated virus (AAV) gene therapy to restore fertility in male infertility models. The research aims to test the feasibility and safety of in vivo Sertoli cell gene therapy in mouse models of non-obstructive azoospermia (NOA), a leading cause of male infertility. Key objectives include identifying novel...
This $169,500 Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research by New York University (NYU) School of Medicine to characterize soma-germline interactions during adult spermatogenesis. The research aims to determine how a secreted, conserved, immunoglobulin (Ig) domain protein maintains the blood-testis barrier in somatic support cells of the...
This $147,486 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will support research conducted by the Trustees of the University of Pennsylvania to investigate the role of the KIF2C protein in regulating the microtubule cytoskeleton during the oocyte-to-embryo transition in early development. The research aims to determine how KIF2C controls the formation of cortical maturation asters...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) aims to determine how male germ cells (MGCs) in the fetal stage respond to and repair double-strand DNA breaks. The $107,458 award to Duke University will fund research to elucidate the molecular mechanisms underlying MGC DNA damage repair and its implications for the development of spermatogonial stem cells (SSCs), which supply sperm...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $152,834 to the University of Toledo to identify biomarkers for the sperm striated columns. The striated columns are a unique structure in sperm that may play a role in sperm motility and zygote centrosome function. The goal is to develop molecular reporters to enable future studies on the...