This federal Project Grant award of $401,927, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to understand the functions of long terminal repeat (LTR) retrotransposon activation in preimplantation development. The grant recipient, Cincinnati Children's Hospital Medical Center, will utilize advanced genetic manipulation techniques such as CRISPR interference and base editing in mouse embryos to systematically evaluate the cis-regulatory functions of retrotransposon subfamilies during zygotic genome activation and early embryogenesis. The goal is to identify specific retrotransposon-derived regulatory elements that are critical for early development, which could provide insights into gene regulation in human embryogenesis and potentially improve reproductive technologies. The project will run from June 1, 2025 through March 31, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $401.9k | 6/4/25 |