Project Grant R01HD118540

Award Date 6/1/25
Completion Date 3/31/30
Dollars Obligated $402K
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Cincinnati, OH 45229, USA
Similar Awards
This federal Project Grant award for $378,123 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) supports research to identify and test mechanisms that establish transcriptional regulatory potency in early embryos. The primary activities include using genomic methods like PRO-seq, DREG, and OMNI-ATAC to characterize transcriptionally active regulatory elements, DNA accessibility, and...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $760,617 to Boston Children's Hospital to conduct research on the mechanisms underlying pluripotency transitions during peri-implantation development. The research aims to identify key transcription factors and understand how DNA methylation regulates the transition from naive to formative...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $364,324 to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University to conduct research on the role of retrotransposable elements (RTEs) in neurodevelopment and disease. The key objectives of this two-year project are to: 1) Investigate the impact of RTE expression...
This $1,080,375 federal Project Grant award was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research by the University of Massachusetts Medical School (UMass Medical) to study the role of maternal transcripts and RNA-binding proteins in reproductive fecundity using the nematode worm Caenorhabditis elegans as a model organism. The research aims to...
This Project Grant award, worth $271,728, was issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research conducted by the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, to uncover the molecular mechanisms that initiate and maintain germ cell identity. The primary goals of the research project are to: (A) discover the mechanisms that...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $125,000.00 in funding to the Whitehead Institute for Biomedical Research to develop novel technologies for integrated mapping of cell state and lineage during normal development. The goal is to create comprehensive cellular and molecular atlases to understand how tissues are assembled and...
This $737,732 federal Project Grant award was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865) to The Trustees of Columbia University in the City of New York, with a period of performance from July 2024 to March 2029. The project aims to study the causes and consequences of DNA replication stress in the mammalian preimplantation embryo. The research will focus on identifying the...
This Project Grant award, valued at $232,500.00, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research to investigate the role of circular RNA (circRNA) in ovarian follicular development and fertility. The project will examine the effect of the KHDRBS1 protein on circRNA biogenesis and its impact on fertility using a granulosa cell-specific KHDRBS1 knockout...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $508,315 to the University of California, San Diego (UCSD) to uncover the molecular mechanisms required for successful developmental progression from oocyte to embryo during the window of transcriptional silence in mammals. The overarching goal is to improve understanding of the earliest stages of mammalian development and the...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $1,576,519.00 to the University of Kansas Medical Center Research Institute, Inc. over the period from August 7, 2024 to May 31, 2029. The award will fund research to investigate the importance of the METTL3 gene in the development and maintenance of the mammalian placenta. The...

This federal Project Grant award of $401,927, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to understand the functions of long terminal repeat (LTR) retrotransposon activation in preimplantation development.

The grant recipient, Cincinnati Children's Hospital Medical Center, will utilize advanced genetic manipulation techniques such as CRISPR interference and base editing in mouse embryos to systematically evaluate the cis-regulatory functions of retrotransposon subfamilies during zygotic genome activation and early embryogenesis. The goal is to identify specific retrotransposon-derived regulatory elements that are critical for early development, which could provide insights into gene regulation in human embryogenesis and potentially improve reproductive technologies. The project will run from June 1, 2025 through March 31, 2030.

Generated 7/1/25, 3:50 AM