Project Grant R01GM161051
- This $306,788 federal Project Grant was awarded on September 30, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports the development of advanced probe technologies for ultrasensitive, quantitative RNA imaging using Hybridization Chain Reaction (HCR) amplification methods. The research aims to enable multiplexed, high-resolution imaging of gene expression patterns in highly autofluorescent...
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,316,016 Project Grant under CFDA Program 93.859 (Biomedical Research and Research Training) to the University of California, Irvine (UCI) to develop a novel biosensing platform for label-free, single-molecule detection at ultra-high speeds using metasurface-enhanced coherent Raman scattering. The 4-year project, running from September 2025 to August 2029, aims to overcome fundamental speed limitations in surface-enhanced...
- This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), provides $372,210.00 to San Diego State University Foundation (SDSU Foundation) to develop fluorescent nucleoside analogues for advancing RNA-centered therapeutics. The key products and services to be delivered under this 5-year award (7/1/2025 - 4/30/2030) include: Creating modified antisense oligonucleotides (ASOs) and...
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
- This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using...
- The National Institute of General Medical Sciences (NIGMS) awarded a $349,243 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. on September 12, 2025. The grant supports the development of an innovative "Spotlight-Omics" workflow that can cost-effectively isolate disease-relevant spatiotemporal phenotypes from live cell cultures for subsequent omics analysis. This workflow aims to address a critical limitation of current...
- This federal Project Grant award of $459,250.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to develop a systematic approach for detecting regulatory RNAs and their functional motifs based on RNA-protein interactions. The key research objectives include: Investigating whether RNA regulates the genomic occupancies of chromatin-associated proteins (CAPs). Employing an...
- This federal Project Grant award of $2,257,345.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new microscope capabilities to enable novel studies of biological processes at the University of North Carolina at Chapel Hill. Specifically, the research will combine new optical principles and computer vision to build autonomous microscopes that can rapidly capture and process...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,890,339 Project Grant under CFDA 93.859, Biomedical Research and Research Training, to the University of California Irvine (UCI) to develop novel "molecular lanterns" for multiplexed imaging of RNA dynamics. The key objectives are to: 1) Generate orthogonal RNA tags and complementary split luciferase binders to enable simultaneous visualization of multiple transcripts; and 2) Establish a platform for continuous, multiplexed bioluminescent imaging using the RNA tools in biologically relevant systems. The project aims to overcome limitations of current RNA imaging approaches by providing a robust, minimally-invasive method to track the location, degradation, and interactions of diverse RNAs in real-time. This foundational research is expected to have broad implications for advancing the understanding of complex biological processes mediated by RNA.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.9m | 8/12/25 |