Project Grant R01GM160503
- This $1,926,960 Project Grant was awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Trustees of Boston University on September 15, 2025. The grant aims to develop new algorithms, engineer speckle illumination, and integrate these technologies into microscopes that enable high-speed, multicolor, and volumetric (multiplane) superresolution imaging using standard fluorescent molecules. The goal is to...
- This federal Project Grant award of $2,257,345.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of new microscope capabilities to enable novel studies of biological processes at the University of North Carolina at Chapel Hill. Specifically, the research will combine new optical principles and computer vision to build autonomous microscopes that can rapidly capture and process...
- This federal Project Grant award, totaling $850,740 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to significantly expand fluorescence spectral multiplexing in tissue imaging. The key objectives are to: Develop a 56-color panel of semiconducting polymer dots (PDots) with narrow absorption and emission bands to enable 56-plex imaging for deep immune profiling of cells in tissue samples....
- The National Institute of General Medical Sciences (NIGMS) awarded a $333,048 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Imagen Bioworks Inc. in Houston, TX. The goal of this 1-year project is to develop a versatile 2-photon microscopy platform, dubbed 2P-SPOTLIGHT, to isolate individual cells from 3D tissue samples and 3D cell cultures based on their spatial and temporal properties. This will enable researchers to conduct downstream multi-omics...
- This federal Project Grant award of $153,000.00, awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), supports the development of a universal imaging technique based on point spread function (PSF) modulation to enable super-resolution capabilities in mobile microscopy platforms, including smartphones. The goal is to overcome resolution limitations of...
- This federal Project Grant award of $349,280 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of advanced machine learning algorithms for ultra-high-density, ultra-high-precision single molecule localization microscopy (SMLM). The grant recipient, Xgenomes Corp., will create a SMLM video simulator to generate training data (Aim 1), build a machine learning-based grouping...
- This Project Grant award of $727,297 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will enable Colorado State University (CSU) to acquire a new 3i Marianas super-resolution spinning disk confocal microscope. This cutting-edge imaging system will enhance CSU's research capabilities across a broad range of biological models, including yeast, mammalian cell culture, organoids, tissue slices, and model...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $330,076 to Trestle Optics LLC, a small disadvantaged business located in Irvine, California. The award supports the development of a novel photothermal microscopy platform integrated with spatial light interference imaging. This innovative instrument is designed to enable non-destructive profiling and mapping of...
- This Project Grant award, valued at $1,963,850.00 and awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a novel "Differentiable Microscopy" technology at the Massachusetts Institute of Technology (MIT). The project aims to create a high-throughput, end-to-end imaging cytometry system by leveraging customizable nano-optics and machine learning techniques. The goal...
- The National Institute of General Medical Sciences (NIGMS) awarded a $290,536 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to Trestle Optics LLC, a small disadvantaged business, to develop a novel high numerical aperture catadioptric lens for ultra-broadband multimodal microscopy. This lens will enable advancements in existing nonlinear optical imaging modalities, such as three-photon excited fluorescence and third-harmonic generation, by overcoming limitations of...
This $1,977,264 federal Project Grant, awarded by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to develop a novel multimodal imaging platform that combines fluorescence super-resolution and tomographic polarized light imaging. The project will create open-source computational imaging tools to recover the dielectric tensor in multiple scattering samples using GPU acceleration, and benchmark the platform's performance on two cellular motility projects. The first project will quantify 3D hydrodynamic flow fields surrounding motile bacteria and their cell fate markers, while the second will measure the local 3D viscoelastic properties and applied forces for eukaryotic cells placed in collagen matrices. This multimodal imaging platform is intended to address critical needs in the field of biological imaging by enabling the study of cellular and unicellular organism dynamics at high speeds.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.0m | 9/8/25 |