Project Grant R01GM160523
- The National Institute of General Medical Sciences (NIGMS) awarded a $347,086 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) to develop "Precision, Functional Glyconanoassemblies Through Supramolecular Design." This research aims to advance the state-of-the-art in synthetic glycan assemblies by employing a coordination-driven self-assembly approach to create multivalent glycomolecules with atomic...
- The U.S. National Institute of General Medical Sciences (NIGMS), through the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded a $432,834 Project Grant to the Board of Regents of the University of Nebraska on April 15, 2025. The grant supports the development of an "enzyme-free, label-free quantitative microarray technology" to detect and quantify target nucleic acids, such as microRNA, with high sensitivity down to the attomolar (10^-18 M) range....
- The National Institute of General Medical Sciences (NIGMS) awarded a $1,890,339 Project Grant under CFDA 93.859, Biomedical Research and Research Training, to the University of California Irvine (UCI) to develop novel "molecular lanterns" for multiplexed imaging of RNA dynamics. The key objectives are to: 1) Generate orthogonal RNA tags and complementary split luciferase binders to enable simultaneous visualization of multiple transcripts; and 2) Establish a platform for continuous,...
- The National Institute of General Medical Sciences (NIGMS) awarded a $306,872 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Fluid Discovery, Inc., a San Francisco-based biotechnology company, to develop a "Universal Platform for Ultrahigh-Throughput Biocatalyst Evolution with Micro-Mass Spectrometry." The award supports the development of a commercial prototype for Fluid Discovery's novel screening platform, which combines scalable hardware,...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
- This $147,091 Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project on plasmonic nanoantenna-enhanced fluorescence immunoassay enabled by super-hydrophobic surfaces. The goal is to develop a transformative fluorescence detection technology that can achieve ultra-low and ultra-sensitive protein detection, which is crucial for early disease diagnosis. The project...
- The federal Project Grant award of $350,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting the development and demonstration of a novel enzyme-based, single-molecule protein sequencing system by Electronic Biosciences, Inc. This innovative platform leverages enzyme-driven processing and sequencing of individual proteins and peptides, combined with advanced bioinformatics, to achieve high...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- The University of California, Los Angeles (UCLA), through its Office of Research Administration, received a $1,354,522 project grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to develop a biosensor for real-time visualization of the spatiotemporal dynamics of the key cellular metabolite acetyl-CoA. The project aims to overcome limitations in understanding the compartmentalized regulation of acetyl-CoA,...
- The National Institute of General Medical Sciences (NIGMS) awarded a Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Maryland, College Park. The $526,451 grant, awarded on May 1, 2025, supports the development of a novel optical microscopy modality for cell biomechanics research based on pulsed stimulated Brillouin scattering (SBS). The goal is to create a non-contact, non-perturbative, and high-resolution system to study the...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,316,016 Project Grant under CFDA Program 93.859 (Biomedical Research and Research Training) to the University of California, Irvine (UCI) to develop a novel biosensing platform for label-free, single-molecule detection at ultra-high speeds using metasurface-enhanced coherent Raman scattering. The 4-year project, running from September 2025 to August 2029, aims to overcome fundamental speed limitations in surface-enhanced Raman-based biosensing to enable practical applications such as rapid DNA sequencing. The project combines expertise in coherent Raman scattering microscopy and advanced dielectric nanoantenna design to deliver a thermally robust enhancement platform capable of label-free single-molecule detection with microsecond signal acquisition times, representing a 10,000-fold improvement over current SERS-based methods.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.3m | 9/11/25 |