Project Grant R01GM160508
- This $1,444,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) aims to develop new cryogenic electron microscopy (cryo-EM) methods to visualize the structural heterogeneity of ribosomes at the single-molecule level in cells. The award, effective September 2, 2024 through August 31, 2027, will enable the principal investigator to pursue strategies to extend a novel technique called 2D template...
- The University of Colorado-Denver was awarded a $1,998,288 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The 4-year grant, commencing on September 1, 2025, will support research to investigate the kinetics of co-translational protein folding in living cells using a novel visualization technology. Specifically, the project aims to quantify co-translational folding in diverse intracellular...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $339,552 Project Grant to the Trustees of the Colorado School of Mines (CSM) on September 1, 2025. The grant supports CSM's research program to investigate the structure-dynamics-function relationships that regulate the biogenesis of protein complexes, with a focus on two families of bacterial proteins - S-layers and microcompartments. The goal is to...
- This Project Grant award of $727,297 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will enable Colorado State University (CSU) to acquire a new 3i Marianas super-resolution spinning disk confocal microscope. This cutting-edge imaging system will enhance CSU's research capabilities across a broad range of biological models, including yeast, mammalian cell culture, organoids, tissue slices, and model...
- The University of New Mexico received a $335,712 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will support the development of high-resolution single-molecule imaging techniques to study protein interactions and organizations in cells. Specifically, the project aims to: 1) Develop a two-color single-particle tracking microscope to study the dimerization of epidermal growth...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $410,014 Project Grant to Trustees of Boston University to establish proof-of-concept for a new high-speed, real-time feedback-driven single particle tracking (RT-FD-SPT) fluorescence microscope with concurrent spectroscopic readout. The goal of this project is to develop an advanced tracking approach that leverages dual-stage scanners and nonlinear...
- The National Institute of General Medical Sciences (NIGMS) awarded a $3,999,999 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Icahn School of Medicine at Mount Sinai (ISMMS). The funding will support the purchase of a Glacios 2 cryo-electron microscope (cryo-EM) to enable ISMMS researchers to conduct advanced structural biology studies on diverse biological systems and disease mechanisms. The new cryo-EM instrument, equipped with a Falcon 4i...
- This $254,182 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), will fund the development of a novel, unified X-ray/cryo-EM pipeline for ensemble-based structural refinement. The project aims to address the significant challenges posed by structural disorder, flexibility, and conformational heterogeneity in modern therapeutic modalities, which limit the accuracy of traditional refinement...
- This $395,455 Project Grant was awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the project is to develop and apply computational methods for biomolecular structural modeling using cryo-electron microscopy (cryo-EM) data. Key products and services to be delivered include: Expanding and enhancing the capabilities of structure modeling methods to improve accuracy and...
- The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $416,625 Project Grant to Saint Louis University under the Biomedical Research and Research Training program (CFDA 93.859) to develop innovative optical tools to control endogenous G protein-coupled receptors (GPCRs) in unmodified cells and in vivo. The project aims to: (1) enable optical control of endogenous GPCRs, (2) control GPCRs and endogenous G proteins at specific subcellular locations like the Golgi and nuclear...
The National Institute of General Medical Sciences (NIGMS) awarded a $2,113,889 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Colorado, Boulder. This 4-year grant, running from September 1, 2025 to August 31, 2029, focuses on enhancing cryogenic sample time-resolved electron microscopy (CryoTREM) capabilities through the development of a patterned LED/LCD-based illumination system. The goal is to capture multiple temporal states of various biological systems, including ligand-gated ion channels, lipid transferases, V-ATPase, and synaptic vesicle fusion, in order to determine ensembles of time-resolved structures and understand underlying molecular mechanisms. The project will produce time-resolved data sets that will be integrated with data processing methods to advance the scientific understanding of these dynamic biological processes.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.1m | 8/6/25 |