Project Grant R35GM157192
- The University of Colorado-Denver was awarded a $1,998,288 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The 4-year grant, commencing on September 1, 2025, will support research to investigate the kinetics of co-translational protein folding in living cells using a novel visualization technology. Specifically, the project aims to quantify co-translational folding in diverse intracellular...
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- This Project Grant award of $501,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research by The Regents of the University of California, San Francisco (UCSF) to develop simulation-based models that can more accurately interpret experimental data in structural biology. The goal is to enhance understanding of how macromolecules communicate and interact, which is vital for advancing...
- The National Institute of General Medical Sciences (NIGMS) awarded a $2,113,889 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Colorado, Boulder. This 4-year grant, running from September 1, 2025 to August 31, 2029, focuses on enhancing cryogenic sample time-resolved electron microscopy (CryoTREM) capabilities through the development of a patterned LED/LCD-based illumination system. The goal is to capture multiple temporal states of...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $321,270 Project Grant to the Massachusetts Institute of Technology (MIT) to support a Computational and Systems Biology (CSB) Ph.D. training program. The objective of the grant is to train the next generation of computational and systems biologists through an interdisciplinary program that integrates biology, computation, and engineering. The program...
- This $1,970,835 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Chicago focused on the multiscale simulation of key biomolecular processes in the cell. The project will employ bottom-up coarse-grained computational models to study protein-protein interactions, protein-mediated membrane remodeling, and the formation and remodeling of actin-based...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $422,931.00 to the University of Colorado-Denver to characterize how specialized microbial metabolites mediate interactions within the human microbiome. The research aims to elucidate the role of these metabolites in enabling microbial communities to resist antimicrobial therapies, with the goal of improving...
- This $244,450 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to understand the catalytic mechanisms, structural dynamics, and biomedical importance of two key classes of metalloenzymes: matrix metalloproteinases (MMPs) and iron(II)/2-oxoglutarate (2OG)-dependent oxygenases. The project, spanning July 2025 to June 2030, aims to provide missing knowledge on these...
- The National Institute of General Medical Sciences (NIGMS) awarded a $361,952 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant supports research to systematically explore the mutational landscape of biomedically relevant proteins such as CRISPR-Cas genome editing enzymes. The goal is to develop experimental methods and machine...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $339,552 Project Grant to the Trustees of the Colorado School of Mines (CSM) on September 1, 2025. The grant supports CSM's research program to investigate the structure-dynamics-function relationships that regulate the biogenesis of protein complexes, with a focus on two families of bacterial proteins - S-layers and microcompartments. The goal is to develop new computational models, simulation strategies, and analysis frameworks to study the spatiotemporal organization of these dynamic protein complexes. This research aims to advance the broader understanding of bacterial biogenesis and could lead to the development of new therapeutics targeting pathogenic bacteria, as well as aid synthetic biology efforts for protein-based biotechnology. The project is scheduled for completion by May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $339.6k | 8/19/25 |