Project Grant R01GM155691
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $444,125.00 to the Rector & Visitors of the University of Virginia (UVA) to conduct research on the molecular mechanisms of protein sorting and localization to organelles. The research aims to uncover how nascent polypeptide chains are processed and folded by chaperones during transport across the endoplasmic...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $400,530 Project Grant to the Rector & Visitors of the University of Virginia (UVA) on June 1, 2025. The grant supports UVA's research to develop next-generation nanodisc tools that can characterize membrane protein-lipid interactions essential for understanding cell-cell interactions and communication. Specifically, the research will focus on...
- This federal Project Grant award of $229,135 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to establish C18-ceramide as an essential factor for ferroptosis, a novel form of regulated cell death, and to elucidate the molecular mechanisms by which C18-ceramide interacts with the NCOA4 protein to regulate ferritinophagy and ferroptosis. The research, conducted by...
- This $398,598 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research on mechanosensing mechanisms in intestinal epithelial cells. The principal investigator will use super-resolution functional imaging and in vivo interactomic approaches to identify conserved molecular machineries that drive mechanochemical sensing in epithelial microvilli, investigate physiological...
- This federal Project Grant award of $394,214 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research on the intracellular transfer of lipids between cell membranes. The grant, awarded to Oregon Health & Science University (OHSU), aims to characterize the lipid transport function of two specific proteins, MPP6 and ATP11A, and determine their 3D structures using cryo-electron microscopy. The...
- The Project Grant award in the amount of $778,444.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research aimed at understanding the structure and function of phospholipids and inositol phosphates in the cell nucleus. The research, conducted by a diverse group at Vanderbilt University Medical Center, focuses on investigating the structural biology and functional genomics of these...
- This Project Grant award, valued at $2,157,780.00, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award will fund research focused on understanding the role and regulation of inflammatory fibroblasts in wound healing, a critical aspect of human health. The research aims to investigate how immune-stromal cell crosstalk contributes to wound healing, as well as whether fibroblasts can...
- This Project Grant award of $484,625.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is supporting research into the spatiotemporal regulation of organelle interactions and metabolism. The principal investigator at The Washington University aims to gain a mechanistic understanding of lipid metabolism, particularly the role of lipid droplets in metabolic diseases like insulin resistance, obesity, and...
- The federal Project Grant award of $420,000 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to identify the molecular mechanisms of mitochondrial dysfunction in pathological stress conditions. The primary objective is to investigate the processes of oxidative phosphorylation and mitochondrial membrane potential disruption, which can lead to cell death and tissue damage in various diseases....
- This federal Project Grant award of $446,875.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to decipher novel cell death mechanisms and metabolic reprogramming in response to microenvironmental stress. The primary awardee, The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania, will leverage their expertise in...
This federal Project Grant award for $353,430, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into the regulation of ceramide-1-phosphate (C1P) metabolism and its role in cellular metabolic reprogramming. The award aims to investigate how C1P and the enzyme ceramide kinase (CERK) regulate mitochondrial function, lipid droplet biosynthesis, and the induction of ferroptotic cell death in response to cellular stressors and proliferation signals. The research is being conducted by the Rector & Visitors of the University of Virginia, a prominent public research university, with a performance period from September 15, 2025 to July 31, 2029. The findings from this grant are expected to advance the understanding of how bioactive lipid signaling networks influence cellular metabolism and immune cell polarization, with potential implications for disease diagnosis and treatment.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $353.4k | 9/11/25 |