This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), aims to unravel the molecular interconnections between circadian rhythms and lipid metabolism. The $574,021 award, effective from February 1, 2025 to January 31, 2030, will be provided to the University of Missouri System to address three key knowledge gaps: 1) how phosphatidic acid (PA) mediates nuclear processes, 2) how...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), provides $422,500.00 in funding from January 1, 2025 to November 30, 2029 to President and Fellows of Harvard College. The award supports research to investigate the regulatory mechanisms underlying autophagic lipid degradation pathways, as well as lipid trafficking and utilization at membrane contact sites within cells. The research...
This federal Project Grant award of $440,454 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) will support a research project focused on epithelial cell mechanobiology in mechanically heterogeneous microenvironments. The primary objectives are to study how epithelial cells sense and respond to extracellular wounds, whether epithelial migration can occur with lower forces by modifying extracellular matrix...
This $307,015 federal Project Grant awarded by the National Science Foundation's Biological Sciences program to the University of Utah aims to investigate the mechanisms regulating the lipid droplet proteome. The research will use multiscale simulations and collaborative experiments to understand how proteins selectively target and interact with lipid droplets in response to varying metabolic conditions. Findings from this work could provide insights to guide future therapeutic interventions for...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,130,886 to The University of Texas Southwestern Medical Center to conduct research on the multimodal regulation of intracellular lipid surveillance. The five-year research project aims to define the molecular mechanisms underlying the lifecycle of the nuclear hormone receptor NHR-49, which plays a key role in lipid sensing and...
The National Institute of General Medical Sciences (NIGMS) has awarded a $1,189,314 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to The Washington University to elucidate the roles of protein disaggregases and develop enhanced disaggregases to counter diverse protein-misfolding disorders. The five-year project, beginning on September 1, 2024, will focus on two primary themes: (1) developing finely-tuned variants of the Hsp104 disaggregase and using them...
This federal Project Grant award of $852,726, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research that aims to elucidate the mechanisms regulating sub-cellular organization and the significance of this organization to organelle and cell function. The award will leverage advanced quantitative microscopy methods developed by the research team to visualize the spatial organization of cells...
This federal Project Grant award of $1,150,541 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to resolve the protein interaction network that drives autolysosomal tethering, a critical step in the autophagy pathway. The primary research objectives are to use in vitro and in vivo techniques, including single particle cryo-electron microscopy and cryo-focused ion beam milling with...
This $440,327 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) supports research to uncover the key factors and mechanisms involved in lipoprotein trafficking to the bacterial outer membrane in Gram-negative bacteria. The primary objectives are to identify the additional lipoprotein trafficking pathways that exist beyond the known Lol pathway, understand how distantly related...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training Program (CFDA 93.859), will support research to define the pathways of polyunsaturated fatty acid autoxidation and the cellular consequences of resulting lipid electrophiles (LEs). The $369,174 award to Louisiana State University, spanning September 1, 2024 to August 31, 2029, aims to use Staphylococcus aureus as a simplified model system to...