Project Grant R35GM158174

Award Date 7/1/25
Completion Date 6/30/30
Dollars Obligated $394K
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Portland, OR 97239, USA
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This Project Grant award of $394,214.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports a multi-year research initiative at Oregon Health & Science University (OHSU) to investigate the intracellular transfer of lipids from one membrane to another.

The key products and services to be delivered under this award include:

  1. Characterization of the lipid transport functions of two proteins, MPP6 and ATP11A, including purification and structural analysis of the recombinant proteins.
  2. Synthesis of new lipid derivatives featuring photo-crosslinking capabilities to identify transient lipid-binding proteins involved in cellular signaling.
  3. Measurement and comparative analysis of lipid interactomes in healthy and virus-infected cells to identify targets crucial for viral infection and replication.

The award period runs from July 1, 2025 to June 30, 2030, building on OHSU's prior research funded under an R01 grant. This work aims to advance the understanding of lipid transport and signaling mechanisms, with potential applications in combating viral infections.

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