This federal Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research to investigate the mechanisms underlying lipoprotein trafficking to the bacterial outer membrane. The award, totaling $440,327.00, is for the period from January 27, 2025 to December 31, 2029. The primary research objectives are to uncover the factors responsible for lipoprotein trafficking in the...
This Project Grant award, provided by the U.S. Department of Health and Human Services' National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training), aims to conduct mechanistic studies and develop predictive modeling to understand how lipids and food impact the absorption of orally delivered compounds, including drugs, nutrients, and toxins. The $930,000 award to Northeastern University, with a project period from September 1, 2024 to June 30, 2029,...
This Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports research on the analysis of bulk lipid transport at membrane contact sites. The $1,491,951 award to the University of Wisconsin System aims to define the essential molecular properties of the BLTP2 protein and understand how its function at membrane contact sites is regulated. This research seeks to uncover the...
This $963,619 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports the development of 3D-printed microfluidic channel architectures to precisely control the structure and properties of lipid nanoparticles (LNPs) for enhanced nucleic acid delivery. The objectives are to: 1) design, simulate, and test 3D channel architectures to manipulate LNP flow conditions and tailor properties; 2)...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to elucidate the molecular machinery underlying lipid and energy storage in lipid droplets within eukaryotic cells. The $609,493 award, granted on June 1, 2025, will fund a 5-year project conducted by the Sloan-Kettering Institute for Cancer Research in New York. Key objectives include: 1) elucidating the structure,...
The Department of Health and Human Services' National Institute of General Medical Sciences awarded Oregon Health & Science University a $2,680,200 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) for the period September 1, 2022 through August 31, 2025. The grant will support research to elucidate signaling pathways of the P2X7 purinergic receptor and develop novel small molecule and aptamer ligand therapies. Specifically, the recipient will utilize...
This federal Project Grant award, valued at $444,262 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859), supports the development of innovative reagents and methods for synthesizing oligophosphate constructs. The key products and services to be delivered include: New methods and reagents for synthesizing oligophosphate chains of increasing length, including pentaphosphate, hexaphosphate, and...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $414,000.00 in funding to Lewis & Clark College to investigate the role of lipid metabolism in the biogenesis of lysosome-related organelles (LROs). The research aims to gain a better understanding of the processes controlling LRO morphology by studying the ACDH-11 gene, which was identified as disrupting the morphology of...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $1,130,886 to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on the multimodal regulation of intracellular lipid surveillance. The 4-year project aims to elucidate the molecular mechanisms by which cells sense and respond to changes in lipid homeostasis, with a focus on understanding...
The federal Project Grant award R35GM156863 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) to investigate the mechanisms and functions of lipid recycling for cellular metabolism. The $422,500 award, spanning January 1, 2025 to November 30, 2029, will enable researchers at President and Fellows of Harvard College to: Elucidate the regulatory mechanisms underlying the autophagic lipid...