The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training federal grant program (CFDA 93.859), awarded a $675,898 Project Grant to The University of Texas Southwestern Medical Center (UT Southwestern) to conduct research on defining the modular architecture of protein intrinsically disordered regions (IDRs) for a predictive understanding of biological function. The 5-year grant, starting on Sep 1, 2024, will use computational approaches, in vitro experiments, and in vivo studies to comprehensively classify IDRs, develop predictive models of IDR function, and delineate how the modular architecture of disordered sequences impacts their conformation and function. This research aims to provide a new level of interpretability and predictability in understanding the functional mechanisms of IDRs, which are a class of protein sequences that do not adopt stable secondary structures.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $337.9k | 7/14/25 | ||
| Not listed | $337.9k | 8/27/24 |