The National Institute of General Medical Sciences (NIGMS) awarded a $752,456 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant, effective September 1, 2024 through July 31, 2029, supports the development and application of innovative, user-friendly computational technologies for identifying new bioactive small molecules and improving their pharmacological properties. Key focus areas include creating a database of...
The National Institute of General Medical Sciences (NIGMS) awarded a $452,250 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant, effective June 1, 2025 through April 30, 2030, supports research to decipher the functions of nuclear speckles in regulating protein quality control processes, which are crucial for cellular health and implicated in conditions like aging and neurodegeneration. The research aims to...
This $385,700 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research at the University of Pittsburgh over a 5-year period from September 2024 to August 2029. The research aims to develop advanced computational and machine learning models that integrate diverse biomedical data, from genetics to transcriptomics and proteomics, to better predict the effects of therapies on diseased cells....
The National Institute of General Medical Sciences (NIGMS) awarded a $275,303 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant will fund a 5-year research project to develop predictive stochastic models that bridge the molecular, cellular, and population scales of microbial proliferation and population dynamics. Specifically, the research aims to: (i) understand the effects of molecular noise on microbial cell size...
The National Institute of General Medical Sciences (NIGMS) awarded a $222,708 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Utah. The grant, effective May 21, 2025 through December 31, 2026, will support a data-driven approach to protein engineering of the aminotransferase enzyme ARO8. The research aims to reveal the non-covalent interactions governing a novel C-C bond forming reaction catalyzed by ARO8, and develop computational...
This federal Project Grant award of $644,900.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on PAS (Period-ARNT-Single-Minded) domain proteins. The research aims to obtain mechanistic insights into how these ubiquitous signaling proteins, found across all kingdoms of life, detect and respond to changes in environmental conditions. Specifically, the research will utilize...
This $1,166,250 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to understand how evolutionary processes, especially natural selection, shape patterns of genetic variation across genomes. The key products and services to be delivered under this 5-year grant, awarded on August 16, 2024, include: Generating better estimates of the genome-wide fitness effects of new mutations, as...
This federal Project Grant award, provided by the National Institute of General Medical Sciences (NIGMS) under CFDA Program 93.859 (Biomedical Research and Research Training), will support the development of innovative computational models to leverage spatially resolved single-cell transcriptomics data. The $198,750 award to the University of Pittsburgh aims to create novel geometric deep learning models that can identify tissue structures and pathologies, and provide the underlying spatial...
The National Institute of General Medical Sciences (NIGMS) has awarded a $294,147 Project Grant under the Biomedical Research and Research Training (CFDA 93.859) program to the University of Kansas Center for Research Inc. The 5-year grant, effective June 1, 2025, will support the development of advanced computational modeling approaches to characterize macromolecular interactions within living cells. The project aims to bridge classical docking and biomolecular simulation methods to enable...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $378,714 to the Rochester Institute of Technology (RIT) to develop novel bio-statistical graph learning strategies for structural characterization of large-scale disease pathways and systematic biomedical data analytics. The goal is to leverage both node features and topological information in protein-protein...