Novel transition metal catalysis for chemical synthesis
Active Project Grant Awarded Last action
- Award ID
- R35GM156632
- Recipient
-
University Of Texas At Dallas UEI EJCVPNN1WFS5
- Awarding agency
-
National Institute of General Medical Sciences
National Institutes of Health, Department of Health and Human Services
- Obligated
- $1,742,458
Award facts
- Assistance listing
- 93.859 Biomedical Research and Research Training
- Completion date 32% complete
- Place of performance
- Richardson, TX 75080, USA
Award details come from USAspending.gov.
Description
- Abstract
- The proposed mira application aims at the development of a new synthetic platform for controlled selective functionalizations of organic molecules. The existing synthetic methods toward complex molecules and pharmaceuticals mostly rely on employment of pre-functionalized substrates. Employment of non- functionalized groups is much more appealing, as these moieties are much more abundant and cheap. Moreover, the aliphatic c(SP3)-h bonds are often present in complex biologically important molecules and pharmaceuticals, and thus their selective functionalization offers a powerful tool for late stage modifications. The few existing methods for functionalization of unactivated saturated groups are not general, as the functionalization site is usually substrate-controlled. Also, these methods operate under acidic conditions and/or employ external oxidants, which limits the substrate scope. Thus, mild regio- and stereo-controlled functionalization of saturated groups remains a holy grail in modern synthetic chemistry. We propose the development of a novel visible light-induced transition metal-radical hybrid catalytic methodology for regiocontrolled, mild, and exogenous oxidant-free functionalizations of saturated groups. The site of intramolecular functionalizations will be controlled by a designed tool-kit of temporary auxiliaries, which potentially in one-pot fashion will be routinely installed onto substrate and removed from the product. The chemo- and stereoselectivity of intermolecular functionalizations will be achieved via design of potent and selective hydrogen atom abstracting groups. The feasibility of a successful development of this project is supported by a vast amount of preliminary results obtained in our lab.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $43,244 | |
| Amendment | $389,194 | |
| Amendment | $389,194 | |
| Amendment | $460,413 | |
| Original award | $460,413 |
Quick answers
Who received award R35GM156632?
R35GM156632 was awarded to University Of Texas At Dallas by National Institute of General Medical Sciences (National Institutes of Health) on April 22, 2025.
How much is award R35GM156632 worth?
$1,742,458 has been obligated on R35GM156632.
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