The Washington University Office of Sponsored Research Services Division has been awarded a $514,876 Project Grant by the National Science Foundation's (NSF) Biological Sciences program (CFDA 47.074). The grant will fund a 5-year research project to develop new computational methods for studying the evolution of intrinsically disordered protein regions (IDRs), which play essential biological roles despite not adopting a defined 3D structure. The project aims to identify signatures of evolutionary conservation in IDR sequences and deploy accelerated artificial evolution techniques to understand how IDRs change under different selective pressures. The research will also involve training the next generation of scientists in computational biology, machine learning, and computer science methods for analyzing IDRs. No subawards are planned for this grant, which commenced on March 1, 2024 and is scheduled for completion by February 28, 2029.
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