This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, is funding research to gain insights into how biological timers control development and how the apical extracellular matrix (AECM) is constructed and remodeled in nematodes. The $381,801 award, effective August 1, 2025 through May 31, 2030, will support three interconnected projects: 1) determining how biological timers...
This $387,500 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand the roles of microRNAs in animal development. The project aims to systematically investigate the functions of highly conserved microRNAs and identify their critical cellular targets, leveraging the C. elegans model organism. The research will yield knowledge on how dosage changes in these...
This Project Grant award from the National Science Foundation (NSF) Biological Sciences program (CFDA 47.074) provides $419,182 to Carleton College to conduct collaborative research on the integration of temporal, positional, and sex-specifying cues in neuronal development. The project will use the nematode worm C. elegans as a model to discover the molecules that regulate the generation of neurons controlling reproductive behaviors. This research aims to elucidate how sex-determining signals...
This Project Grant award, provided by the National Science Foundation (NSF) under the Biological Sciences (CFDA 47.074) program, aims to uncover the intricate ways neurons communicate and how this communication influences brain development and maturation. The $360,000 award, effective from April 1, 2025 to March 31, 2030, will support research at the University of Alabama at Birmingham (UAB) to investigate the role of neuron-neuron communication, particularly through neurotransmitter-based and...
This federal Project Grant award of $651,596 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research by the Cold Spring Harbor Laboratory (CSHL) to study the molecular mechanisms that coordinate gene expression, cell fate determination, and tissue growth during development. The key research objectives are to: 1) Determine the molecular structures and dynamics of three transcriptional complexes that regulate...
This $1,737,000 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports the development of innovative single-cell genomics technologies for joint analysis of regulatory dynamics and transcriptional states. Key objectives include: Developing multiomics tools to measure rates of epigenomic changes (DNA methylation, demethylation, oxidative damage, DNA repair) and relate these to...
This federal Project Grant award of $985,026 from the National Institute of Neurological Disorders and Stroke (NINDS) under CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders, aims to investigate the roles and mechanisms of epitranscriptomic regulation in the development and function of the mammalian nervous system, as well as the pathological consequences of disrupting these processes. The research program will utilize mouse models and human induced...
This Project Grant award of $565,826, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports research conducted by Duke University to investigate the signaling and gene regulatory mechanisms that enable nematodes (C. elegans) to adapt to fluctuations in nutrient availability. The research aims to close knowledge gaps in understanding the role of tumor suppressors DAF-18/PTEN and LIN-35/RB in...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), is funding a research project titled "Connecting Circadian Clock Dynamics to Metabolism and Fitness" at the University of Chicago. The $435,126 award, spanning January 2025 to December 2029, aims to quantitatively understand the relationship between the circadian clock and external environmental factors that support...
This Project Grant award, valued at $1,380,568.00 and provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program, supports an interdisciplinary research initiative led by the University of Chicago. The project aims to develop a multiscale, predictive understanding of how cells adapt to changes in their environment, with potential applications in innovative therapeutic interventions for diseases. The research is...