Project Grant R01GM153779
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $406,250.00 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, for a research project titled "Novel Molecules as a Window to Anesthetic Mechanisms". The goal of this 5-year project is to uncover new mechanistic targets for general...
- This Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 - Biomedical Research and Research Training) supports a research program investigating the potential neurotoxic effects of anesthetic and sedative drugs on brain development. The $426,250 award to The Johns Hopkins University will fund a 5-year research project to determine whether exposures to these drugs during critical developmental windows in humans can impair the formation of neural circuitry and...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $394,160 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to study the impact of common anesthetics on lymphatic vessel contractility and extracellular fluid uptake. The goal of this research is to use advanced lymphatic imaging techniques in a novel murine critical care model to...
- This federal Project Grant award, valued at $453,750.00 and effective September 1, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research program led by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to advance the understanding of perioperative neurocognitive disorders (PND) and their association with disruptions in...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $705,726 to New York University School of Medicine to conduct a multi-center feasibility randomized clinical trial on the use of monitored anesthesia care with soft-tissue infiltration of local anesthesia (MAC-STILA) for older adults undergoing hip fracture surgery. The trial aims to assess the feasibility of randomizing patients to MAC-STILA versus the current standard of general...
- This federal Project Grant award, valued at $358,313.00, was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The award will fund a 5-year research study at Drexel University to investigate how prior knowledge shapes the learning and long-term consolidation of new memories in healthy human adults. The research will utilize functional neuroimaging (fMRI) and...
- This $441,626 federal Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training program) to the Trustees of Dartmouth College. The grant supports the development of a wireless, soft implant with a protruding microneedle sensor array to continuously and comprehensively track organ physiology and biochemistry. The goal is to elucidate the pathophysiology of perioperative organ injury (POI) and the...
- The U.S. Department of Health and Human Services National Institutes of Health (NIH) awarded a $226,464 Project Grant under the Trans-NIH Research Support program (CFDA 93.310) to the University of Wisconsin-Milwaukee on June 11, 2025. The grant funding will support research to demonstrate the therapeutic efficacy of gamma aminobutyric acid type A receptor (GABAAR) modulators in reducing acute lung injury caused by inhaled chlorine exposure. The research aims to develop medical countermeasures...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $161,500.00 to investigate the role of perineuronal nets (PNN) in the development of postoperative delirium in aged mice. The research aims to test the hypothesis that changes in PNN and parvalbumin-positive neurons coincide with delirium-like cognitive impairment in aged mice subjected to anesthesia, surgery, and intensive care unit (ICU)-like conditions. The project will also examine whether...
- This federal Project Grant award, valued at $503,535.00 and awarded on September 4, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The project aims to develop novel protein-based gamma-aminobutyric acid (GABA) sensor modules using bacterial GABA regulators (GABR) to facilitate the understanding of GABA neurotransmission, which is implicated in various mental health conditions. The...
This federal Project Grant award of $334,325.00 was provided by the National Institutes of Health (NIH), National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research project titled "GENERAL ANESTHETIC MODULATION OF MEMORY THROUGH ALPHA5-GABA(A) RECEPTORS ON LAMP5-EXPRESSING INTERNEURONS" at the University of Wisconsin - Madison. The objective of the research is to understand the mechanism of general anesthesia and the role of hippocampal GABA(A) receptors in the suppression of learning and memory. The 1-year project will test hypotheses related to the effects of anesthetics like etomidate, propofol, midazolam, sevoflurane, and ketamine on memory processes and the underlying neural mechanisms involving specific interneuron subtypes. The findings are expected to advance the basic scientific understanding of how memory is supported and controlled by interneurons in neural circuits.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $334.3k | 8/28/25 |