Project Grant R15GM160979
- This federal Project Grant award of $390,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research on the structural dynamics of G protein-coupled receptor (GPCR) oligomerization and its impact on cellular localization and signaling. The 5-year award, effective August 1, 2025, will fund investigations into the complexes formed between GPCRs, G proteins, β-arrestins, and GPCR kinases,...
- This federal Project Grant award of $329,976 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to establish a multiscale modeling strategy to simulate ion selectivity in proteins. The principal investigator will utilize novel force fields to conduct molecular dynamics simulations that provide structural, dynamic, and thermodynamic insights into protein-ion interactions. The research aims to analyze the...
- This federal Project Grant award of $512,397, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to examine the structure of the intracellular domain (ICD) of glycine receptors in lipid bilayers. The research aims to use cross-linking mass spectrometry (CXMS) techniques to characterize the ICD structure in different allosteric states and investigate lipid-protein interactions. This...
- This federal Project Grant award of $348,963.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports fundamental scientific research to investigate the mechanisms of quorum signal synthesis in gram-negative bacteria, with the goal of establishing molecular determinants for substrate recognition and developing quorum sensing inhibitors as potential anti-virulence compounds. The...
- This $1,970,835 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at the University of Chicago focused on the multiscale simulation of key biomolecular processes in the cell. The project will employ bottom-up coarse-grained computational models to study protein-protein interactions, protein-mediated membrane remodeling, and the formation and remodeling of actin-based...
- This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $388,158.00 to the University of California, Los Angeles (UCLA) to engineer a highly active and selective gamma-Aminobutyric Acid (GABA) oxidase enzyme. The goal is to develop a high-performance, implantable, electroenzymatic GABA microsensor that can monitor GABA transients in the...
- This $694,875 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Boston University Medical Campus to advance the understanding of G protein-coupled receptor (GPCR) and heterotrimeric G protein signaling plasticity. The research aims to define the physiological implications of non-GPCR activation of G proteins and develop innovative tools to measure G protein activity....
- This $576,104 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports fundamental research on the molecular mechanisms underlying transmembrane conduction and signaling in integral membrane proteins. The research aims to define the structural transitions and energy coupling processes that drive and regulate cyclical processes in membrane proteins, with a focus on understanding voltage...
- This federal Project Grant award of $349,566 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of a Spotting-Free Nano-Oscillator Array (SFNOA) technology for high-throughput, label-free quantification of ligand binding kinetics to transmembrane proteins in their native states. The key products and services delivered through this award include: Integration of innovative technologies...
- The U.S. National Institute of General Medical Sciences (NIGMS) awarded a $416,625 Project Grant to Saint Louis University under the Biomedical Research and Research Training program (CFDA 93.859) to develop innovative optical tools to control endogenous G protein-coupled receptors (GPCRs) in unmodified cells and in vivo. The project aims to: (1) enable optical control of endogenous GPCRs, (2) control GPCRs and endogenous G proteins at specific subcellular locations like the Golgi and nuclear...
This federal Project Grant award, valued at $503,535.00 and awarded on September 4, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The project aims to develop novel protein-based gamma-aminobutyric acid (GABA) sensor modules using bacterial GABA regulators (GABR) to facilitate the understanding of GABA neurotransmission, which is implicated in various mental health conditions. The proposed work focuses on enhancing the stability and sensitivity of GABR-based biosensors, as well as optimizing chemically labeled "semisynthetic" sensors for improved spectral tuning and kinetics. These novel GABA sensors are intended to be valuable tools for investigating GABA neurotransmission in live cells, brain slices, and in vitro assays, with potential applications in drug discovery and in vivo neurological research. The award recipient is Loyola University of Chicago, a private, non-profit Jesuit Catholic university with a strong track record in federal grant awards, particularly in the areas of biomedical research and specialized medical services.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $503.5k | 9/3/25 |