This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the effects of anesthetic and sedative exposure on brain development. The $426,250 award, effective from July 1, 2025 to June 30, 2030, will fund studies using cutting-edge translational laboratory approaches to determine whether anesthetic and sedative exposure poses a risk to human brain health. Specifically, the research will examine the impact of these exposures on the formation of synapses and myelin, which are critical for the development of neural circuitry. The program will also investigate the underlying molecular mechanisms, specifically related to the mechanistic/mammalian target of rapamycin signaling system, to provide insights that can help move this field forward. This research is aimed at addressing a fundamental knowledge gap regarding the potential neurotoxicity of anesthetic and sedative drugs on human brain development.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $426.3k | 6/26/25 |