This Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to advance the field of native mass spectrometry (MS) analysis. The $316,825 award, effective May 1, 2025 through April 30, 2026, supports the development of an innovative intact mass deconvolution method designed to improve the speed, accuracy, and user-friendliness of proteins and nucleic acid molecular weight...
The National Institute of General Medical Sciences (NIGMS) awarded a $340,920 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the Board of Regents of the University of Nebraska. The goal of this 5-year project is to develop novel top-down and native mass spectrometry approaches to directly characterize and quantify intact ribosomal proteins and determine the specialized components that assemble into heterogeneous ribosome structures. This research...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $585,000 in funding to the University of Texas at Dallas (UTD) for the period of August 1, 2025 to May 31, 2030. The grant supports two key objectives: Developing innovative strategies and platforms for discovering 'natural product'-like macrocyclic peptides as potent and selective modulators of biomolecular interactions. This...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $762,960 to the University of Texas at Austin to develop localized real-time sensors for monitoring intracellular metabolic signaling. The research aims to deconvolute the signaling roles of metabolites by creating genetically encoded fluorescent biosensors that can measure specific metabolite concentrations and fluctuations within...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $244,450 in funding to Michigan Technological University from July 1, 2025 to June 30, 2030. The award supports research to investigate the catalytic mechanisms, structure-function relationships, and dynamics of two key classes of metalloenzymes - matrix metalloproteinases and 2-oxoglutarate-dependent oxygenases. The...
This Project Grant award from the National Institutes of Health (NIH) Office of Research Infrastructure Programs (CFDA 93.351) provides $593,598 to the University of Texas Medical Branch at Galveston (UTMB) to acquire a Waters DESI XS XEVO TQ Absolute mass spectrometry imaging system. This specialized equipment will enhance UTMB's bioimaging capabilities in drug discovery and development research across areas of infectious disease, kidney disease, and neuroscience. The award supports...
This federal Project Grant award in the amount of $271,495.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports the development and evaluation of a time-of-flight (TOF) mass spectrometer system with matrix-assisted laser desorption/ionization (MALDI) for fast analysis of antibodies and related macromolecular immune complexes. The goal is to utilize a novel high-temperature superconducting...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $202,274 to develop an easy-to-use computer program for predicting the structure and degrading efficiency of proteolysis targeting chimeras (PROTACs). PROTACs are heterobifunctional molecules that induce the degradation of target proteins by recruiting them to E3 ubiquitin ligases. The awarded project aims to implement a...
The National Institute of General Medical Sciences (NIGMS) awarded a $344,400 Project Grant (CFDA 93.859 - Biomedical Research and Research Training) to The University of Texas Southwestern Medical Center to develop new tools and approaches for improving cryo-electron microscopy (cryo-EM) and cryo-electron tomography (cryo-ET) imaging techniques. Specifically, the grant aims to: 1) Develop a sample preparation strategy to reduce electron-induced radiolysis of frozen-hydrated biological...
This National Science Foundation (NSF) Project Grant award under the Mathematical and Physical Sciences program (CFDA 47.049) provides $343,638 to Texas A&M University-Commerce to conduct research on the thermochemistry, reaction dynamics, and conformational changes associated with the collisional activation of peptide ternary complexes and recombinant tagged proteins. The key products and services to be delivered through this 3-year grant include: Developing new zinc- and nickel-binding...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $387,375 to the University of Texas Medical Branch at Galveston (UTMB) for a research project titled "Protein Turnover Estimation from Fragment Ions and Precursor Enrichment in Heavy Water Labeled LC-MS Experiments".
The project aims to develop new techniques to improve the accuracy, throughput, and statistical power of protein turnover estimation using heavy water metabolic labeling and liquid chromatography-mass spectrometry (LC-MS). Specifically, the research will explore estimating protein turnover from isotope labeling of fragment ions in tandem mass spectra, and develop a computational model of label incorporation that accounts for individual amino acid labeling kinetics. The goal is to enable more comprehensive analysis of in vivo protein turnover to support studies on disease mechanisms and biomolecular dynamics. The project period runs from September 10, 2024 to August 31, 2028.