Project Grant R43GM156165
Award Date
9/4/24
Completion Date
8/31/25
Dollars Obligated
$202K
Federal Agency
National Institute of General Medical Sciences
Awardee
Acpharis (E4Z3M7L7NHT3)
Federal Grant Program
93.859
Assistance Type
Project Grant
Place of Performance
Holliston, MA 01746, USA
Similar Awards
The National Institute of General Medical Sciences (NIGMS) awarded a $752,456 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The grant, effective September 1, 2024 through July 31, 2029, supports the development and application of innovative, user-friendly computational technologies for identifying new bioactive small molecules and improving their pharmacological properties. Key focus areas include creating a database of...
This $584,420 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research into spatiotemporal mapping and engineering of the "dark proteome" - intrinsically disordered proteins and their functions. The principal objectives of the grant are to: (1) investigate the role of protein disorder in facilitating transport through the nuclear pore complex, including developing...
This federal Project Grant award, provided by the National Science Foundation (NSF) under the Mathematical and Physical Sciences (CFDA 47.049) program, supports the development of experimental and theoretical frameworks for optimizing targeted protein degrader compounds. The $492,000 award, spanning July 2024 to June 2029, allows Professor Ferguson at the University of California, San Diego to evaluate the kinetic parameters of targeted protein degradation across the kinome and develop new...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) provides $435,620 to The Regents of the University of California, San Francisco (UCSF) to develop and test algorithms for iteratively docking subsets of ultra-large small molecule libraries against molecular targets. The goal is to create a more efficient prioritization approach for virtual screening of trillion-scale make-on-demand small...
The National Institute of General Medical Sciences (NIGMS) awarded a $243,840 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Pittsburgh. The project, titled "An Effective Statistical Inference Framework to Develop Innovative Compensations for Protein Mutations," aims to develop quantitative methods for predicting the impact of protein mutations and identifying compensatory mutations that can restore normal protein...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $502,043 in funding to Brandeis University. The research program aims to investigate how transition metals shape catalysis and allostery in metalloproteins, focusing on two key enzyme superfamilies: viral proteases and SAMHD1 dNTPases. The project will dissect the metal-dependent activities of viral proteases from...
This Project Grant award of $388,621 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support the development of novel molecular designs with therapeutic potential. The key objectives are: Developing ligand-heterocycle conjugates as targeted RNA degraders with rapid kinetics and selectivity for cancer-associated G-quadruplexes. Engineering nucleic acid polymers with (thio)phosphoramidate backbones as biostable...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, provides $379,131 to the University of North Carolina at Chapel Hill to conduct research aimed at accelerating the development of macromolecule-based therapeutics. The key objectives are to: 1) establish rapid characterization assays to assess the conformation and dynamics of disordered peptides and peptidomimetics, 2)...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the development of engineered enzymes that can be activated to perform targeted modifications of cellular proteins. The $1,602,000 award to the Dana-Farber Cancer Institute, Inc. (DFCI) will fund research to design and apply novel autoinhibited enzymes that can toggle between inactive and active conformations in response...
This $385,700 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will fund research at the University of Pittsburgh over a 5-year period from September 2024 to August 2029. The research aims to develop advanced computational and machine learning models that integrate diverse biomedical data, from genetics to transcriptomics and proteomics, to better predict the effects of therapies on diseased cells....