This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training (CFDA 93.859) program, is focused on advancing the understanding of the mechanisms of iron-sulfur enzymes. The $647,301 award, effective February 1, 2025 through January 31, 2030, will fund research at the Massachusetts Institute of Technology (MIT) to: Develop synthetic models of iron-sulfur enzyme intermediates to elucidate their reaction...
This $368,110 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to study the structures and properties of key enzymatic intermediates involved in oxygenase chemistry. The research aims to develop peptide-based synthetic models that can mimic the active sites and reactivity of non-heme iron and copper oxygenases, which are critical for metabolism, natural product...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $343,203 to the Regents of the University of Michigan to elucidate the biological process of heme insertion into cytochrome P450 enzymes. The research aims to characterize the role of tubulin and define the role of HSP70 in the heme insertase machinery, as well as to characterize the heme insertase for the specific...
This federal Project Grant award of $123,737.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to advance drug discovery for protein domains containing intrinsically disordered regions. The award was granted to the Regents of the University of Michigan, a prominent U.S. state government-owned educational institution, with a performance period from October 1, 2024 to April 30, 2025. The NIGMS...
This Project Grant award of $357,056.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training (CFDA 93.859) program supports research to adapt heterogeneous materials and macromolecules for use in high-throughput experimentation (HTE) approaches in organic synthesis. The key objectives are to: 1) develop colloidal suspensions of insoluble inorganic reagents to enable their use in automated HTE workflows, 2) create material and...
The National Institute of General Medical Sciences (NIGMS) awarded a $147,656 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, Davis. The grant will fund advanced spectroscopic studies of enzymatic intermediates containing iron-sulfur clusters. Specific objectives include: Characterizing the paramagnetic intermediates of the biotin synthase enzyme BioB, which utilizes an uncommon [4Fe-5S] auxiliary cluster, using electron...
The National Institute of General Medical Sciences (NIGMS) awarded a $350,487 Project Grant under the Biomedical Research and Research Training Program (CFDA 93.859) to the University of Illinois to support research on "Uncovering Novel Heme Chemistry in Microbial Systems." The project aims to expand understanding of how diverse bacterial diheme proteins stabilize high-valent bis-FeIV states and leverage these intermediates for site-specific substrate oxidation. Key focus areas include...
This federal Project Grant award of $419,375 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports research to define the functional dynamics of multi-domain redox enzymes, such as nitric oxide synthase (NOS), which are crucial for diverse signaling processes and disease states. The research aims to provide unprecedented understanding of how regulatory interactions and modifications...
The National Institute of General Medical Sciences (NIGMS) awarded a $1,148,562 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of Texas at Dallas. The grant, effective August 1, 2024 through May 31, 2029, will fund research to develop a computational framework to investigate the biochemical and biophysical mechanisms of transmembrane anion and transition metal transporters. The project aims to advance scientific understanding of the...
This $597,945 federal Project Grant awarded by the National Science Foundation's (NSF) Division of Chemistry under the Mathematical and Physical Sciences (CFDA 47.049) program supports research by Tobias W. Giessen at the University of Michigan, Ann Arbor to investigate the structure and function of peptide-modifying enzyme filaments found in bacteria and archaea. The proposed work will generate new insights into the self-assembly and catalytic activity of these filamentous enzymes, which...