Project Grant R01EY038806
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, Davis $423,767 under the Vision Research program (CFDA 93.867) for a two-year project period beginning June 1, 2025 and concluding May 31, 2027. The research project investigates the role of myeloid cells as mediators of glaucomatous axon degeneration and evaluates whether nicotinamide adenine dinucleotide (NAD+)-boosting interventions provide neuroprotection through anti-inflammatory...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded a $701,576 Project Grant to the University of California, San Diego, effective July 1, 2026, through April 30, 2030, under the Vision Research program (CFDA 93.867). The award funds research to explore endogenous retinal ganglion cell (RGC) repair mechanisms following injury using engineered human pluripotent stem cell (PSC)-derived three-dimensional retinal organoids as a model system. The research addresses the...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded University of California, Davis a $719,012 Project Grant effective August 1, 2025, through July 31, 2030, to optimize suprachoroidal adeno-associated virus (AAV) delivery systems for retinal gene therapies in nonhuman primates. The research addresses significant limitations of conventional AAV administration routes by evaluating microcatheterization techniques and...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $255,722 to the University of California, Berkeley, effective September 15, 2025, through August 31, 2027. This Project Grant funds research investigating the role and regulation of a distinct optic nerve microglia population in glaucomatous neuropathy. The research addresses mechanisms of retinal ganglion cell degeneration during ocular hypertension (OHT) by examining...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded a $902,000 Project Grant to The Regents of the University of California, San Francisco under the Vision Research program (CFDA 93.867) effective September 1, 2025, through August 31, 2027. This award funds research to characterize a novel GLIS1 knockout (KO) mouse model of glaucoma, addressing the critical need for therapeutic strategies targeting neuroprotection in primary open-angle glaucoma (POAG), a leading cause of...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded the University of California, San Francisco a Project Grant of $737,998 effective July 1, 2026, through March 31, 2031, under the Vision Research program (CFDA 93.867). This award funds research to define area-specific cellular and circuit-level specialization in the human temporal cortex, with particular focus on identifying electrophysiological and synaptic features unique to excitatory neurons in the inferior...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $545,948 to The Schepens Eye Research Institute, Inc. under the Vision Research program (CFDA 93.867) beginning April 1, 2026, through March 31, 2030. This Project Grant funds basic and translational research to understand the role of reactive astrocytes in glaucoma pathogenesis. The research deliverables will include scientific findings on how astrocytes in the optic nerve head respond to ocular hypertension,...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $481,500 to the Regents of the University of California, doing business as University of California, Berkeley, effective September 1, 2025, through August 31, 2027. The project, titled "A Role for Retinal Waves in Vascular Development," will deliver research aimed at understanding neural-glial-vascular signaling mechanisms that influence blood vessel...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded $127,180 under the Vision Research program (CFDA 93.867) to The Regents of the University of California, San Francisco, effective July 1, 2026, through June 30, 2028. This two-year project grant funds basic science research investigating the role of perivascular retinal ganglion cells (RGCs) in regulating retinal vascular architecture and neurovascular resilience. The research focuses on a specialized subset of RGCs...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $125,954 to the University of California, Berkeley for a two-year Project Grant (July 1, 2026 – June 30, 2028) to conduct fundamental research on the molecular mechanisms underlying synaptic specificity in the retinal direction-selective circuit. The research addresses how neurons form precise synaptic connections during development and investigates the relevance of these...
The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $437,262 to the University of California, Davis for a project investigating the functions of PAX2-expressing astrocytes in postnatal retinal and optic nerve development. The award, effective July 1, 2026, through March 31, 2030, will deliver research findings addressing the underlying causes of human ocular disorders, particularly congenital cavitary optic disc anomalies (CODA), morning glory disc anomaly syndrome (MGDA), glaucoma, and optic neuritis. The research will utilize advanced methodologies including conditional Cre-Lox mouse genetics, immunohistochemistry, confocal and electron microscopy, small animal ocular imaging (optical coherence tomography and scanning laser ophthalmoscopy), flow cytometry, and single-cell next-generation sequencing with bioinformatics analysis. The project will generate mechanistic insights into PAX2+ astrocyte functions during retinal vasculature development and homeostasis, as well as their roles in retinal ganglion cell axon health and oligodendrocyte-mediated myelination. Expected deliverables include molecular profiling data from lineage cells and contributions to understanding central nervous system myelination and demyelinating diseases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $437.3k | 6/24/26 |