The federal Project Grant award F31EY037171 was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to The Johns Hopkins University. The $147,486 award, effective June 1, 2025 through May 31, 2028, will support research to evaluate the regenerative potential of human retinal ganglion cells (RGCs) and their ability to regrow the optic nerve and restore visual function. The project aims to systematically investigate how modulating intrinsic...
This $428,349 Project Grant awarded by the National Eye Institute (CFDA 93.867 Vision Research) supports research by The Medical College of Wisconsin, Inc. to investigate the mechanisms controlling the development of retinal ganglion cells (RGCs). The key objectives are to: Examine the shared cis-regulatory elements and target genes of the transcription factors ATOH7, POU4F2, and ISL1 that are critical for RGC genesis. This will involve testing their spatial-temporal expression patterns in...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $427,625 to the University of Wisconsin-Madison to conduct research on defining folate-dependent single-cell methylomic and transcriptomic networks in distinct retinal ganglion cell (RGC) types associated with axon regeneration. The research aims to isolate and analyze regenerating versus non-regenerating RGCs to identify molecular profiles that distinguish RGC...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate the role of neural activity in improving retinal ganglion cell (RGC) replacement therapies for glaucoma. The $132,597 award to The Schepens Eye Research Institute, Inc. aims to: 1) characterize retinal remodeling following RGC inactivation, and 2) determine if inhibiting host neural activity can enhance the structural and functional integration...
The National Eye Institute (NEI) awarded a $240,000 Project Grant (CFDA 93.867 - Vision Research) to Baylor College of Medicine to conduct research focused on "Characterization of the Nascent Retinal Proteome Regulating Hippo Signaling During Damage." The project aims to use cell type-specific metabolic labeling and purification techniques to identify the immediate molecular regulators of the Hippo signaling pathway in muller glial cells of the damaged mouse retina. This information is...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $665,243 to The Ohio State University to research methods for enhancing retinal ganglion cell (RGC) survival and optic nerve regeneration using cytokine-polarized myeloid cells. The goal is to develop autologous myeloid cell therapies and therapeutic cocktails that can promote visual recovery in individuals with optic neuropathy. Key activities include elucidating the reparative factors secreted...
This $414,711 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) will support research at Albert Einstein College of Medicine to develop human organoid models for studying retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding. The goal is to elucidate the mechanisms underlying early optic disc and stalk development, RGC differentiation, and axon growth and pathfinding in human development and retinal diseases like glaucoma. The researchers...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) supports research to investigate the cellular and molecular mechanisms underlying the pro-regenerative effects of conditioning lens injury on retinal ganglion cells (RGCs) and their axon regeneration after optic nerve crush. The $168,396 award to the Regents of the University of Michigan, effective February 1, 2025, will fund two specific aims: 1) Loss-of-function and gain-of-function studies on the role...
This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, under the Vision Research (CFDA 93.867) program, provides $500,500 to support research on the role of retinal ganglion cells in shaping the identity and function of neurons in the superior colliculus visual processing region. The key objectives are to: 1) determine how retinal input influences the morphology and transcriptional profiles of genetically-defined neuron...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $1,241,223 to the University of Pittsburgh to conduct research on the genetic and epigenetic circuits underlying retinal transcription programs and how perturbations in the retinal core regulatory networks lead to congenital vision disorders. The key objectives are to: 1) Use mouse models to dissect the molecular, cellular, and genomic effects of genetic mutations on retinal development; 2)...