The University of Pittsburgh received a National Eye Institute (NEI) Vision Research Program (CFDA 93.867) Project Grant award of $413,741 to conduct research on the genetic and epigenetic mechanisms underlying retinal development and the chromatin landscape in retinal progenitor cells. The project aims to provide a deeper understanding of the transcriptional programs and regulatory networks that drive retinogenesis, with the goal of enhancing strategies to diagnose, treat, and prevent congenital vision deficiencies. The 5-year award begins on September 1, 2024 and runs through March 31, 2029. Key research objectives include dissecting the molecular, cellular, and genomic effects of genetic mutations on retinal development, elucidating how transcription factors wire the chromatin landscape in retinal progenitor cells, and exploring how coordination among components of the core regulatory network epigenetically and transcriptionally drives retinogenesis.
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