This Project Grant awarded by the National Eye Institute (CFDA 93.867 Vision Research) provides $695,018 over a 5-year period starting August 1, 2025 to The Johns Hopkins University to conduct research on regulating retinal ganglion cell regeneration using Müller glia cells in zebrafish as a model. The key objectives are to: 1) Identify genes that regulate retinal ganglion cell regeneration and determine if they have universal or context-specific effects across other retinal cell types; 2)...
This $414,711 Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) will support research at Albert Einstein College of Medicine to develop human organoid models for studying retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding. The goal is to elucidate the mechanisms underlying early optic disc and stalk development, RGC differentiation, and axon growth and pathfinding in human development and retinal diseases like glaucoma. The researchers...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $427,625 to the University of Wisconsin-Madison to conduct research on defining folate-dependent single-cell methylomic and transcriptomic networks in distinct retinal ganglion cell (RGC) types associated with axon regeneration. The research aims to isolate and analyze regenerating versus non-regenerating RGCs to identify molecular profiles that distinguish RGC...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $1,241,223 to the University of Pittsburgh to conduct research on the genetic and epigenetic circuits underlying retinal transcription programs and how perturbations in the retinal core regulatory networks lead to congenital vision disorders. The key objectives are to: 1) Use mouse models to dissect the molecular, cellular, and genomic effects of genetic mutations on retinal development; 2)...
The federal Project Grant award F31EY037171 was provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to The Johns Hopkins University. The $147,486 award, effective June 1, 2025 through May 31, 2028, will support research to evaluate the regenerative potential of human retinal ganglion cells (RGCs) and their ability to regrow the optic nerve and restore visual function. The project aims to systematically investigate how modulating intrinsic...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate the role of neural activity in improving retinal ganglion cell (RGC) replacement therapies for glaucoma. The $132,597 award to The Schepens Eye Research Institute, Inc. aims to: 1) characterize retinal remodeling following RGC inactivation, and 2) determine if inhibiting host neural activity can enhance the structural and functional integration...
This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, under the Vision Research (CFDA 93.867) program, provides $500,500 to support research on the role of retinal ganglion cells in shaping the identity and function of neurons in the superior colliculus visual processing region. The key objectives are to: 1) determine how retinal input influences the morphology and transcriptional profiles of genetically-defined neuron...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $665,243 to The Ohio State University to research methods for enhancing retinal ganglion cell (RGC) survival and optic nerve regeneration using cytokine-polarized myeloid cells. The goal is to develop autologous myeloid cell therapies and therapeutic cocktails that can promote visual recovery in individuals with optic neuropathy. Key activities include elucidating the reparative factors secreted...
This Project Grant award of $526,841 from the National Eye Institute (CFDA 93.867 - Vision Research) will support research at Vanderbilt University Medical Center (VUMC) to investigate the role of cGMP signaling in glaucomatous neurodegeneration. The goal is to probe the mechanisms of retinal ganglion cell (RGC) degeneration in glaucoma, a leading cause of irreversible blindness, in order to identify novel therapeutic targets to protect and potentially restore vision. The research will focus...