This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $393,008.00 to the University of California, Davis to conduct research on axonal regeneration in the frog Xenopus laevis. The goal is to systematically understand how this species successfully recovers from optic nerve injuries and regains vision, with the potential to translate these findings into therapies. Key activities include live imaging-based experiments to investigate the roles of the DLK and...
The National Eye Institute (NEI) awarded a $431,750 Project Grant under the Vision Research program (CFDA 93.867) to the University of California, Irvine (UCI) to develop a novel femtosecond laser-based approach for non-viral corneal gene delivery. The key objectives are to create microchannels through the corneal epithelium to enhance transepithelial diffusion, and use subthreshold laser pulses to open membrane pores in stromal keratocytes for safer plasmid-based gene delivery without the...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), is funding the development of OPGX-RHO, a single-vector gene therapy for the treatment of autosomal-dominant retinitis pigmentosa (ADRP). The $882,971 award supports two key objectives: 1) completing chemistry, manufacturing, and controls for a clinical-grade batch of OPGX-RHO, including stability studies and device compatibility testing, and 2) conducting efficacy and...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) is funding research to develop an innovative gene therapy approach using self-amplifying and self-splicing RNA technologies. The $346,500 award, spanning September 2024 to September 2026, aims to evaluate the longevity, immunogenicity, and potential in vivo side effects of this novel mRNA-based therapy for treating inherited retinal dystrophies. The award recipient, The...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to investigate the role of myeloid cells in axon damage and degeneration associated with glaucoma. The research aims to determine whether NAD+-boosting interventions, which have shown promise in promoting axon protection, work through an anti-inflammatory mechanism by inhibiting myeloid cell recruitment. The award provides $423,767.00 over a 2-year period...
This $499,116 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to develop stem cell-derived neuronal relays to regenerate the optic nerve and restore vision. The key objectives are to: 1) measure the functional recovery from long-term optic nerve grafted neural stem cells in the injured visual system, 2) investigate the role of guidance cues on directing neuronal relay axons through the optic chiasm, and 3) target the...
This Project Grant award of $620,149 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports a multi-center research program to develop advanced genome editing technologies for modifying critical genetic risk factors associated with age-related macular degeneration (AMD). The research team, led by the University of Iowa, will conduct base editing and prime editing of AMD risk loci in human cells, including induced pluripotent stem...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to develop a mutation-independent therapy for retinal degenerations caused by mutations in the PRPH2 gene. The $431,750 award will fund research to determine the efficacy of reducing rhodopsin levels, a key component of photoreceptors, as a potential treatment approach across multiple mouse models expressing different PRPH2 mutations. The research will evaluate...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...
This Project Grant award of $947,974 from the National Eye Institute (CFDA 93.867 Vision Research) supports research to understand how the retina and visual system adapt to dynamic changes in light intensity encountered in natural environments. The overarching goal is to examine retinal coding under these naturalistic conditions to determine how diverse adaptation mechanisms across photoreceptors, interneurons, and retinal ganglion cells collectively shape visual signaling to the brain. The...