This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to evaluate the regenerative potential of human retinal ganglion cells (RGCs) and the regrowth of the optic nerve. The $147,486 award to The Johns Hopkins University aims to identify intrinsic factors that regulate RGC survival, axonal outgrowth, and functional recovery in a regenerative animal model, the zebrafish. The research will also test how modulation of these...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $492,500.00 to The Schepens Eye Research Institute, Inc. to develop universally immune-compatible induced pluripotent stem cells (iPSCs) for regenerative applications in various eye conditions. The key objectives are to generate iPSCs expressing peptide-free or low-affinity peptide-loaded major histocompatibility complex (MHC) class I molecules, which are expected...
This Project Grant award, provided by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports research to understand how the retina adapts to photoreceptor loss in retinal degeneration. The $624,230 award to the University of California, Los Angeles (UCLA) spans May 1, 2025 to April 30, 2029. The research aims to document changes in rod photoreceptor function and connectivity as degeneration progresses, as well as investigate plasticity in retinal...
This Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $414,711 to Albert Einstein College of Medicine to establish and utilize a microphysiological system for elucidating the mechanisms underlying early optic disc and stalk development, retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding in human development and the pathogenesis of blinding retinal diseases. The award aims to gain a deeper understanding of RGC differentiation and...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will provide $475,000 in funding to The Salk Institute for Biological Studies in La Jolla, CA. The goal of this 4-year research project is to characterize the connectivity and functional role of specific neural circuits in the mammalian visual system that transmit information from the retina to the primary visual cortex. The key products and services to be delivered include:...
The National Eye Institute (NEI) awarded a $107,948 Project Grant under its Vision Research program (CFDA 93.867) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The grant will support a 4-year research study to develop a novel multimodal optoelectronic device and use optogenetic techniques to investigate the biophysical mechanisms underlying cortical stimulation and its effects on neural dynamics and visual-spatial...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), will support research to investigate the molecular, cellular, and transcriptional mechanisms that regulate reactive astrocyte function in the optic nerve head and retina. The research aims to discover new biological pathways that control glial reactivity, with the goal of developing gliotherapeutics for the treatment of glaucoma and other optic neuropathies. The $2,260,440 award...
This $665,243 Project Grant, awarded by the National Eye Institute under the Vision Research program (CFDA 93.867), supports research at The Ohio State University to investigate the use of polarized myeloid cells for enhancing retinal ganglion cell (RGC) survival and optic nerve regeneration. The research aims to elucidate the factors secreted by interleukin-4 and granulocyte-colony stimulating factor polarized bone marrow neutrophils that promote neuroprotective and pro-regenerative effects,...
This Project Grant award of $437,310, provided by the National Eye Institute (CFDA 93.867 Vision Research program), supports research to study the molecular and physiological mechanisms underlying retinal remodeling following photoreceptor degeneration. The key objectives are to elucidate the genetic, morphological, and physiological changes in retinal ganglion cells that lead to hyperactivity and corruption of visual circuits, with the goal of informing strategies to prevent or reverse...
This Project Grant award from the National Eye Institute (NEI), under the CFDA program 93.867 Vision Research, is funding the development of an injectable optoacoustic retina prosthesis for high-precision retinal stimulation. The PI, Prof. Chen Yang, and Co-I, Prof. Serge Picaud, are leading a multi-disciplinary team to create a minimally invasive retinal prosthesis with micrometer-scale spatial resolution. The $1,765,704 award will enable the team to develop a biocompatible optoacoustic...