This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports a collaboration between the University of Northern Colorado (UNC) and researchers to develop novel biophysical models of eye morphogenesis processes. The $413,920 award, effective August 1, 2024 through July 31, 2027, will fund the creation and validation of quantitative models for choroid fissure closure in zebrafish and foveal pit formation across species. Key...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $306,118 to Eyescreen, Inc. to develop a new drug screening platform using viable human donor eyes. The key goals are to: Establish ex vivo preclinical models for human ocular diseases by restoring and preserving in vivo-like light responsiveness in postmortem human eyes procured up to 1 hour and stored for over 48 hours. Develop a high-throughput screening...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $651,846 to The Johns Hopkins University to identify gene regulatory networks that control the temporal patterning of retinal progenitor cells and neurogenic Müller glia. The research aims to determine the necessary and sufficient transcription factors that specify early versus late-stage retinal progenitor cell identity, and investigate whether these factors can...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $1,241,223 in funding to the University of Pittsburgh to conduct research on the chromatin landscape and transcriptional programs in retinal progenitor cells. The goals of the project are to: 1) dissect the molecular, cellular, and genomic effects of genetic mutations on retinal development; 2) elucidate how the chromatin landscape is wired by transcription factors in retinal...
The National Eye Institute (NEI) awarded a $592,457 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Children's Hospital Corporation, doing business as Boston Children's Hospital. The award will support a research project titled "Neurophysiology of Melanopsin Photoreceptors" from September 30, 2024 to August 31, 2029. The project aims to characterize the response features of intrinsically photosensitive retinal ganglion cells (ipRGCs), which capture...
The federal Project Grant award R01EY036459 in the amount of $435,052 was provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) to the University of Massachusetts Boston. The award supports a research project to investigate the mechanisms that specify different subtypes of photoreceptor neurons for color vision in the Drosophila melanogaster retina. The key focus areas include determining how a binary switch controls blue- versus green-sensitive...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will support research to understand the 3D chromatin organization of the mouse retina at single-cell resolution. The $146,922 award, made on January 30, 2025, will enable The Johns Hopkins University to capture chromatin interactions during key stages of retinal development and examine how transcription factors like NFI regulate chromatin structure to control retinal...
This Project Grant award from the National Eye Institute (NEI), under the Federal Grant Program Vision Research (CFDA 93.867), will fund research to investigate how the microbiome impacts the development of the visual system. The University of Oregon, the awardee, will use the gnotobiotic zebrafish model to determine the role of specific host cell types and secreted bacterial products in visual system development and behavioral outputs. The $364,324 award runs from September 1, 2024 to March 31,...
This $210,899.12 Project Grant awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) will support research to elucidate the gene regulatory networks that drive neural regeneration in the central nervous system. The overarching objective is to profile changes in gene regulation that cause retinal pigment epithelium (RPE) cells to lose their neural competency as they differentiate. Specific aims include interrogating transcription factor...
The National Eye Institute (NEI) awarded a $3,120,397 Project Grant (CFDA 93.867 - Vision Research) to the Medical University of South Carolina (MUSC) to characterize the responses of a 3D retinal pigment epithelium (RPE)/choroid tissue chip model to genetic risk factors and environmental stressors relevant to age-related macular degeneration (AMD). The project aims to elucidate the influence of genetic variants on complement system activity and identify potential therapeutic targets in the...