The National Eye Institute (NEI) awarded a $684,891 Project Grant (CFDA 93.867 Vision Research) to the Massachusetts Eye and Ear Infirmary in Boston, MA. The four-year grant, effective September 30, 2024, supports research to understand the functional consequences of rare genetic variants of unknown significance that contribute to inherited retinal degenerations, a leading cause of blindness. The key objectives are to: 1) Develop and apply a high-throughput splicing assay to identify rare coding...
This National Eye Institute (NEI) Project Grant award under CFDA 93.867 "Vision Research" provides $606,034 in funding to St. Jude Children's Research Hospital to investigate the role of Müller glia in the acute and chronic inflammatory response to stress, injury, and disease in the retina. The project aims to build on the hospital's prior research profiling the inflammatory response in human and mouse retinae, as well as its database of genetic mouse models of human retinopathies. The...
The National Eye Institute (NEI) awarded a $132,597 Project Grant under the NEI Vision Research program (CFDA 93.867) to The Schepens Eye Research Institute, Inc. The grant supports research aimed at improving retinal ganglion cell (RGC) replacement therapies for glaucoma. The project will investigate the role of neural activity in regulating host RGC integration and remodeling of host-donor visual neural circuits. The research involves developing models to selectively inhibit host RGC...
The National Eye Institute (NEI) awarded a $277,197 Project Grant under the Vision Research program (CFDA 93.867) to Boston Children's Hospital, a non-profit academic medical institution. The grant, which has an award date of Aug 1, 2024 and an ultimate completion date of Jul 31, 2029, aims to investigate the social determinants of health that contribute to disparities in vision outcomes for children with amblyopia, a leading cause of preventable vision loss. The research will leverage large...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) in the amount of $477,109 to The University of Texas Southwestern Medical Center to research how the PRDM13 transcriptional regulator gene influences retinal cell development and the formation of photoreceptors. The research aims to further understanding of mammalian retinal development and identify mechanisms by which PRDM13 impacts cell fate determination during a critical window of retinal development....
This $1,789,542 Project Grant awarded by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research at St. Jude Children's Research Hospital to identify and characterize modular super-enhancers that regulate key transcription factor genes critical for retinal development in mice and humans. The research aims to provide a comprehensive map of promoter-super-enhancer interactions in the developing retina, which could help elucidate the genetic basis of...
This federal Project Grant award, provided by the National Eye Institute (NEI) under the Vision Research grant program (CFDA 93.867), supports research focused on understanding how specific retinal ganglion cells (RGCs) interact with nearby blood vessels and vascular factors to modulate visual signal processing. The $116,888 award, effective from September 30, 2024 to August 31, 2026, aims to study the role of mechanosensitive PIEZO2 channels in RGCs located near blood vessels and how they...
The National Eye Institute (NEI) awarded a $487,862 Project Grant under the Vision Research program (CFDA 93.867) to the University of Washington. The grant, with a period of performance from September 1, 2024 to May 31, 2029, will support research to understand how the retina adapts to dynamic changes in light intensity encountered in natural environments. The overarching goal is to investigate how diverse retinal adaptation mechanisms work together to provide reliable visual signaling to the...
This $651,846 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to identify the gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia. The project aims to determine the specific transcription factors necessary and sufficient to control the progressive changes in retinal progenitor cell competence over developmental neurogenesis. Key objectives include profiling...
The National Eye Institute (NEI) awarded Tufts Medical Center a 5-year, $421,600 Project Grant (CFDA 93.867 - Vision Research) to investigate the regulatory mechanisms that govern the growth and regression of abnormal blood vessels in the retina, which can lead to vision loss in conditions like retinopathy of prematurity. The project aims to delineate the roles of chemokine signaling in recruiting peripheral immune cells that promote neovascular growth, as well as the function of microglial...