Project Grant R01EY036365
- The National Eye Institute awarded Baylor College of Medicine $646,167 on April 1, 2026, for investigations of cellular and molecular mechanisms underlying age-related macular degeneration (AMD) under the Vision Research program (CFDA 93.867). The project applies high-throughput functional genomics approaches to test whether non-coding risk variants in AMD exert their effects through gene expression regulation enriched within specific functional networks in disease-relevant tissues. The work...
- The National Eye Institute awarded The Research Foundation For The State University Of New York $248,737 on June 1, 2026, under the Vision Research program (CFDA 93.867) to support research on the role of mitochondrial and autophagy dysfunction in regulating inflammatory processes during age-related macular degeneration pathogenesis. The award funds investigation into the deregulation of autophagy and heightened inflammation implicated in dry AMD, the leading cause of blindness in the elderly...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $733,137 to the University of California, Los Angeles on September 15, 2025, under the Vision Research program (CFDA 93.867) to explore how genetic variation influences disease progression and therapeutic response in age-related macular degeneration. The project integrates advanced optical coherence tomography imaging with machine learning and artificial intelligence to classify...
- The National Eye Institute awarded Baylor College of Medicine $1.6 million on September 30, 2025, under the Vision Research program (CFDA 93.867) to conduct basic research on Hippo and Wnt pathway regulation of mammalian Müller glial cell reprogramming and proliferation as a strategy for retinal regeneration in glaucoma, macular degeneration, diabetic retinopathy, and traumatic retinal injury. The research employs genetic loss- and gain-of-function experiments, fate mapping, and single-cell...
- The National Eye Institute awarded The Methodist Hospital Research Institute $1,029,472 on May 1, 2026, under the Vision Research program (CFDA 93.867) to develop mitochondrial-based cell therapy for age-related macular degeneration. The recipient will create a sustainable source of mitochondria proximal to the retinal pigment epithelium using mesenchymal stem cells transfected with nuclear respiratory factor 1 (NRF1), a driver of mitochondrial biogenesis. The work aims to determine how NRF1...
- The National Eye Institute awarded The Leland Stanford Junior University $666,976 on August 1, 2026, under the Vision Research program (CFDA 93.867) to map age-related macular degeneration (AMD) using precision proteomics and molecular aging analysis. The recipient will deploy the TEMPO (Tracing Expression of Multiple Protein Origins) platform to profile protein biomarkers and identify cellular drivers of AMD in living patients using human liquid biopsy samples. TEMPO integrates aptamer-based...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- The National Eye Institute awarded Baylor College of Medicine $100,228 on March 22, 2027, under the Vision Research program (CFDA 93.867) to validate endothelial mediators in glaucoma neurovascular dysfunction using ligandomics technology. The recipient will independently validate the binding selectivity of glaucoma-associated endothelial ligands to ocular hypertensive versus healthy retinal vessels and verify their functional roles in retinal ganglion cell loss and neurovascular dysfunction...
- The National Eye Institute awarded Trustees of Tufts College (doing business as Tufts University School of Medicine) $504,304 on April 15, 2026, under the Vision Research program (CFDA 93.867) to conduct mechanistic research on the gut-retina axis and its role in age-related macular degeneration. The research tests whether gut microbiota mediate diet-related protection against AMD-like retinal degeneration in mice. The project will conduct fecal microbiota transplantations to transfer...
- The National Eye Institute awarded The Schepens Eye Research Institute $545,948 on April 1, 2026, under the Vision Research program (CFDA 93.867) to support Project Grant R01EY037230, "Understanding the Role of Reactive Astrocytes in Glaucoma." The award funds research into how astrocytes—the primary cellular component of the optic nerve head—become reactive in glaucoma and alter their support of retinal ganglion cells. The project investigates metabolic changes in astrocytes exposed...
The National Eye Institute awarded Baylor College of Medicine $487,986 on September 1, 2026, under the Vision Research program (CFDA 93.867) to dissect retinal glial regulatory mechanisms and refine age-related macular degeneration risk loci through high-throughput functional genomics. The research applies innovative genomics approaches to test the hypothesis that retinal glial function is modulated by AMD risk variants in genes enriched within specific functional networks. The work addresses a critical knowledge gap by functionally testing AMD genome-wide association study variants to pinpoint causal variants and regulatory regions, moving beyond genetic identification toward mechanistic understanding of immune cell dysregulation and neuroinflammation in AMD. The investigator team has identified 81 candidate genes showing abundant expression in microglia and astrocytes through machine learning analysis of transcriptomes from approximately 500 normal and AMD samples, and observed distinct differences in microglial cellular composition between normal and diseased individuals. Performance occurs in Texas with a period from September 1, 2026, through March 31, 2030. The award is structured as a Project Grant, the standard assistance type for NIH R01 research applications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $488.0k | 8/26/26 |