This $615,979 Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate a promising peptide-based combination therapy for restoring structure and function in the diabetic cornea. The key objectives are to: 1) establish the therapeutic role of TB4 and VIP as a combination treatment against diabetes-induced corneal complications; and 2) elucidate the DDR-TRP axis, a novel pathway responsive to hyperglycemic...
The National Eye Institute (NEI) awarded a $670,496 Project Grant (CFDA 93.867 - Vision Research) to Baylor College of Medicine to investigate the paradoxical role of anti-VEGF therapy in subretinal fibrosis associated with neovascular age-related macular degeneration (NAMD). The project aims to elucidate the mechanisms by which anti-VEGF drugs, while effective in alleviating choroidal neovascularization (CNV) in early stages, can exacerbate subretinal fibrosis in later stages of the disease....
This $2,174,069 Project Grant awarded by the National Eye Institute's (NEI) Vision Research federal grant program (CFDA 93.867) aims to develop innovative therapeutic interventions for Fuchs' Endothelial Corneal Dystrophy (FECD). The grant, awarded to the Trustees of the University of Pennsylvania, will support a two-pronged research approach: Elucidating the regenerative potential of corneal endothelial cells (CECs) and the molecular pathways regulating their proliferation, using advanced...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides USD 431,750 to the University of California, Irvine to develop a novel, laser-based approach for non-viral corneal gene delivery. The project aims to create micro-channels through the corneal epithelium to enhance transepithelial diffusion of therapeutic DNA, and use sub-threshold femtosecond laser pulses to open membrane pores in stromal cells without damaging...
This federal Project Grant award R01EY036027 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) aims to develop a novel eye drop-based treatment for neovascular age-related macular degeneration (NAMD) and other ocular diseases with neovascular sequelae. The $436,695 grant supports research and development activities over a 4-year period from July 2024 to June 2028. The key products and services being delivered under this award include: 1) developing and...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) aims to develop a novel high-resolution corneal imaging system. The project will investigate a speckle illumination holographic imaging approach that can capture 3D information over the width and depth of the cornea, while also providing polarization-sensitive data on corneal anisotropy. The $237,996 award, spanning February 2025 to January 2027, will fund the...
The University of North Texas Health Science Center at Fort Worth received a $185,000 Project Grant award from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to discover novel disease-modifying therapies for the prevention and treatment of glaucoma. The research project aims to employ computational pharmacological approaches to identify small molecule inhibitors that can interfere with the GREM1-BMP protein-protein interaction, a key pathogenic...
The National Eye Institute (NEI) awarded a $543,037 Project Grant (CFDA 93.867 - Vision Research) to New York University School of Medicine to support research on the development and function of corneal lens-secreting cells. The funding will be used to: Investigate how cell type-specific gene expression in retinal cone and pigment cells, which contribute to corneal lens formation, is regulated by transcription factors and chromatin accessibility. Examine how the timing of cone and pigment cell...
This Project Grant award from the National Eye Institute (NEI), part of the Vision Research federal grant program (CFDA 93.867), will provide $753,959 to Baylor College of Medicine over the period of June 1, 2024 to May 31, 2029. The project aims to investigate the mechanistic connections between retinal ganglion cell (RGC) activity, resilience, and axon regeneration following traumatic injuries and optic neuropathies like glaucoma. The research will employ cutting-edge approaches to dissect the...
The National Eye Institute (NEI) awarded a $933,533 Project Grant (CFDA 93.867 - Vision Research) to Revopsis Therapeutics, Inc. to conduct Investigational New Drug (IND)-enabling preclinical studies on their transformational trispecific Fab protein RO-104. RO-104 targets vascular endothelial growth factor-A (VEGF-A), VEGF-C, and angiopoietin-2 to address unmet needs in ophthalmology, particularly for the treatment of age-related macular degeneration and other retinal diseases. The two-year...