This Project Grant award of $462,072 from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research at Tufts Medical Center to study the metabolic basis of retinopathy of prematurity (ROP) and explore potential treatments using anaplerotic substrates. The research aims to understand the fatty acid metabolic exchanges between the liver and retina that contribute to oxygen-induced retinopathy development in premature infants. The project will utilize...
This Project Grant award of $184,117, provided by the National Eye Institute (NEI) under CFDA 93.867 Vision Research, supports research at Oakland University to investigate the role of G-coupled protein receptors GPR31 and GPR39 in the pathogenesis of diabetic retinopathy.
The key objectives are to determine the affinities and substrate specificities of GPR31 and GPR39 for 12- and 15-HETE metabolites in retinal endothelial cells and Müller cells under normal and hyperglycemic conditions. The...
This $670,623 five-year Project Grant award from the National Eye Institute (NEI), under the 93.867 Vision Research federal grant program, supports research to characterize changes in ocular structures and retinal function associated with prediabetes and type 2 diabetes progression. The research aims to improve early detection and management of vision loss in prediabetes and type 2 diabetes by examining links between systemic glucose regulation, vascular/neural retina changes, corneal/tear...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), is focused on using optical sensors to measure synaptic glutamate release from retinal rod photoreceptor cells. The $190,538 award, with a performance period from January 1, 2025 to December 31, 2026, will support the development and characterization of a genetically-modified mouse line that allows constitutive expression of an improved glutamate sensor in rod...
This $144,362 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) supports research to understand the molecular mechanisms involved in the breakdown of the outer blood-retinal barrier in diabetic retinopathy. The study aims to investigate the spatial localization and functions of the tight junction protein claudin-19 in the retinal pigment epithelium, and test the hypothesis that regulation of RPE claudins by hyperglycemia and...
This Project Grant award from the National Eye Institute (NEI), which falls under CFDA Program 93.867 (Vision Research), provides $107,727 in funding to Pennsylvania State University's Milton S. Hershey Medical Center to conduct research on the molecular mechanisms underlying diabetic retinopathy. The key objectives are to characterize how diabetes-induced allosteric regulation of the REDD1 protein contributes to its increased abundance in the retina, and to evaluate the role of REDD1...
This $139,693 project grant award from the National Eye Institute (CFDA 93.867 - Vision Research) to the University of California, Irvine will investigate the mechanistic basis for age-related changes in retinal pigment epithelium (RPE) lipid metabolism and their influence on RPE cell function. Key research activities include:
Assessing the retinal structure, visual function, visual cycle activity, and phagocytic ability of ELOVL2-deficient mice at various ages
Analyzing changes in gene...
This Project Grant award of $385,000 from the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) supports research aimed at understanding how interleukin-6 (IL-6) signaling pathways in Müller glial cells affect vascular endothelial growth factor (VEGF) expression and contribute to the development of diabetic retinopathy. The research will investigate the differential effects of IL-6 "cis-signaling" and "trans-signaling" on VEGF...
This federal Project Grant award, provided by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to investigate the role of the signaling molecule Rap1B in regulating the balance between homeostatic and inflammatory responses in retinal endothelial cells during the progression of diabetic retinopathy. The total funding amount is $603,488, with a project period from September 30, 2024 to August 31, 2029. The prime recipient is Versiti Wisconsin,...
This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides funding of $469,854 to the Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences) to conduct research on the mechanisms of diabetic retinopathy. The research aims to investigate the contribution of histone deacetylase 6 (HDAC6) and sirtuin-1 (SIRT-1) to retinal vascular senescence and diabetic microangiopathy, as well as explore...