Project Grant R01EY035290

Award Date 9/1/24
Completion Date 4/30/29
Dollars Obligated $2.1M
Federal Grant Program
93.867
Assistance Type
Project Grant
Place of Performance
Baltimore, MD 21218, USA
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Developing a cortically-induced blindness animal model in ferrets to characterize neuronal and circuit adaptations post-V1 lesions (Aim 1). Separate cohorts of lesioned ferrets will then undergo specialized training regimes to assess neurophysiological adaptations induced by optimal training paradigms (Aims 2-3). Retrograde tracing and neurochemistry will determine the contributions of distinct cell types and neuronal circuits to passive plasticity versus training-induced vision recovery (Aim 4).

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