This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, is aimed at developing an innovative approach to mutational fingerprinting of environmental exposures. The primary goals are to: Quantify the levels of circulating cell-free DNA (cfDNA) in blood after treatment with two different environmental hepatocarcinogens, aflatoxin B1 (AFB1) and N-nitrosodimethylamine (NDMA), to determine the temporal...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $567,093 Project Grant (CFDA 93.113 - Environmental Health) to the University of California, Berkeley to study the impact of wildfire exposure on DNA methylation and health outcomes. The project aims to: 1) develop comprehensive wildfire exposure assessments for a cohort of 5,000 adults in Northern California; 2) collect additional health, lifestyle, and exposure data from the cohort; and 3) conduct a pilot study on 400...
This federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, provides $206,198 to New York Medical College to investigate the role of DNA polymerase delta 4 (POLD4) in lung carcinogenesis induced by genotoxic carcinogens. The project aims to characterize the effects of lung carcinogens, including hexavalent chromium, benzo(a)pyrene, and nicotine-derived nitrosamine ketone, on the degradation of the...
The National Institute of Environmental Health Sciences (NIEHS) awarded a $156,250 Project Grant under the Environmental Health (CFDA 93.113) federal grant program to the University of Toledo Health Science Campus Division. The grant, titled "SWI/SNF in Ultraviolet Radiation-Induced Chromatin Alterations," will support research to investigate the impact of BRG1, a subunit of the SWI/SNF chromatin remodeling complex, on the response of melanocytes to ultraviolet radiation (UVR)...
This federal Project Grant award of $646,476.00, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program, supports research to understand how environmental chemicals, specifically inorganic arsenic, trigger deregulation of the epigenome that can resist epigenetic reprogramming in germ cells, potentially leading to heritable effects. The key objectives are to: 1) assess the developmental reprogramming of arsenic-induced...
This $394,309 Cooperative Agreement award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to maintain, enrich, and enable broader use of the Arkansas Rural Community Health (ARCH) cohort study. The project will: Expand collaborations and hire underrepresented minority (URM) faculty and staff to promote scientific and workforce diversity. Enrich the ARCH cohort with environmental exposure data and social determinants...
This $463,375 federal Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health program (CFDA 93.113) supports research at the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The research aims to identify and characterize the role of melanin-carbonyl-DNA (MCD) and melanin-carbonyl-protein (MCP) adducts in the progression and treatment resistance of NRAS mutant melanoma. The key objectives are to...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) Federal Grant Program, provides $431,750.00 in funding to the University of California, Irvine (UC Irvine) to support research investigating the mechanisms by which environmental agents that suppress transcription trigger innate immune responses. The key objectives of this 2-year project are to: 1) Explain how environmental agents that impede transcription...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program will support the development of high-throughput functional assays and analytical frameworks to measure DNA repair capacity across all major pathways at single-cell resolution. The $390,366 award to the Broad Institute of MIT and Harvard will enable the creation of a library of DNA repair reporter plasmids that can signal repair activity through...
This $350,000 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS), under the Environmental Health (CFDA 93.113) program, supports research at the University of New Mexico Health Sciences Center (UNM HSC) to characterize the impact of uranium-bearing dust (UBD) on the intestinal epithelium. The key objectives are to: 1) determine how UBD exposure affects the intestinal mucosal surface, including thinning of the mucus layer and dysfunction of goblet cells,...