This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program provides $206,198 to New York Medical College (NYMC) to study the role of DNA polymerase delta 4 (POLD4) in lung carcinogenesis induced by genotoxic carcinogens.
The key objectives of this research project are to: 1) characterize the effects of lung carcinogens like hexavalent chromium, benzo(a)pyrene, and nicotine-derived nitrosamine ketone on the degradation of the p12 subunit of POLD4, and 2) investigate whether p12 depletion facilitates neoplastic transformation of lung epithelial cells and enhances urethane-induced lung tumor formation. This research leverages NYMC's expertise in DNA repair mechanisms and lung cancer biology to better understand how POLD4 dysfunction may contribute to lung tumorigenesis driven by exposure to environmental carcinogens. The award has an initial project period from Jun 18, 2024 to May 31, 2026.
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