Project Grant R03ES037466

Award Date 5/10/25
Completion Date 5/9/27
Dollars Obligated $157K
Federal Grant Program
93.113
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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This Project Grant award, provided by the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) Federal Grant Program, supports research on the role of albumin and other serum factors in the accumulation and toxicity of per- and polyfluoroalkyl substances (PFAS) in the body. The $385,219 award, with a project period from May 2025 to February 2030, aims to determine whether albumin is a key factor for PFAS distribution, elimination, and...
The National Institute of Environmental Health Sciences (NIEHS) awarded Wayne State University a 3-year, $1,644,161 Project Grant under the Environmental Health program (CFDA 93.113) to study the effects of per- and polyfluoroalkyl substances (PFAS) on atherosclerosis and cholesterol metabolism. The project aims to determine if PFAS mixtures accelerate atherosclerosis in a mouse model, assess how PFAS disrupts bile acid reuptake and leads to increased cholesterol levels, and evaluate the...
This $260,993 Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program supports Framergy Inc., in collaboration with Texas A&M University, in developing a novel at-home test kit for detecting a broad range of per- and polyfluoroalkyl substances (PFAS) in drinking water. The project leverages Framergy's expertise in metal-organic frameworks (MOFs) and visible light-activated peroxydisulfate to enable complete...
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This Project Grant award of $157,437 from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to define the urinary, biliary, and fecal excretion of per- and polyfluoroalkyl substances (PFAS) and the impact of dietary fiber. The key products or services to be delivered under this award include:

  1. Analyzing samples collected from humanized PPARA mice exposed to seven common PFAS in drinking water and fed different diets, including those supplemented with dietary fibers and cholestyramine, to establish proof of principle that enterohepatic recirculation is critical to maintaining high PFAS body burdens.

  2. Defining the effect of PFAS on transporter expression that could modify PFAS toxicokinetics.

The coordinated analyses under this R03 grant and a related TERP grant are expected to generate the toxicokinetic, physiological, and molecular evidence needed to clarify the role of enterohepatic recirculation in PFAS toxicity. The award period runs from May 10, 2025 to May 9, 2027.

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