Project Grant R01EB038310
- Federal Grant Award Summary Massachusetts Institute of Technology (MIT) received a $266,664 Project Grant award from the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), effective August 18, 2025, with a completion date of July 31, 2027. The award supports a five-year research initiative focused on developing functional mapping methodologies to measure translation initiation kinetics across the human genome. The primary deliverable is the...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $397,712 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded June 20, 2025, with completion scheduled for January 31, 2028. The research investigates the role of extracellular matrix (ECM) in cardiac defects associated with Down syndrome (trisomy 21), addressing a critical knowledge gap in understanding congenital heart...
- Federal Grant Award Summary The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Massachusetts General Hospital a $133,077 Project Grant effective May 1, 2026 through April 30, 2028 under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The grant supports development of a novel deep learning methodology for multi-modal biomedical data fusion that integrates three distinct data sources—clinical notes,...
- Federal Grant Award Summary Massachusetts General Hospital received a $1.485 million Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310), effective September 1, 2025, through August 31, 2028. The award supports discovery and characterization of programmable biological systems derived from bacterial-viral interactions, with particular emphasis on RNA-guided molecular machines beyond traditional...
- Federal Project Grant Award Summary MIT received $1,041,774 in funding from the National Science Foundation (NSF) Division of Molecular and Cellular Biosciences under the Biological Sciences program (CFDA 47.074) for a collaborative research project running from August 1, 2025, through July 31, 2029. This project grant supports fundamental research investigating analog information storage in chromatin states, with the goal of understanding how cells encode and maintain their identity through...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $149,264 Project Grant from the National Institute of General Medical Sciences under the Biomedical Research and Research Training program (CFDA 93.859), awarded March 1, 2026, with completion targeted for September 24, 2028. The award funds structural investigations into the regulatory states of human ribonucleotide reductase (RNR), an essential enzyme for DNA synthesis and repair. The research utilizes cryogenic...
- Federal Grant Award Summary Massachusetts Institute of Technology received a $3.93 million Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded August 15, 2025, with completion targeted for July 31, 2029. The award supports the development of high-throughput quantitative phase microscopy (QPM) imaging systems based on customizable nano-optics to advance imaging cytometry capabilities....
- Federal Project Grant Award Summary Massachusetts Institute of Technology received a $397,034 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), awarded September 1, 2025, with completion scheduled for July 31, 2027. The grant supports development of a transcatheter manufacturing toolkit for creating patient-specific, minimally-invasive left atrial appendage occlusion (LAAO) devices to prevent stroke in...
- Federal Project Grant Award Summary The National Institute of General Medical Sciences (NIGMS) awarded Massachusetts Institute of Technology a $321,270 Project Grant effective July 1, 2025, through June 30, 2030, under the Biomedical Research and Research Training program (CFDA 93.859). The award supports an Interdisciplinary Graduate Training program for the Next Generation of Computational and Systems Biologists, which provides predoctoral training fellowships to develop leaders in...
- Federal Project Grant Award Summary Massachusetts General Hospital received a $412,500 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), effective August 7, 2025 through June 30, 2030. The award funds a five-year research initiative investigating stem cell and progenitor cell quality assurance mechanisms mediated by macrophages during development and tissue regeneration. The project employs...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded Massachusetts Institute of Technology a Project Grant of $678,583 on May 14, 2026, under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to develop synthetic genetic controller circuits that autonomously regulate transcription factor expression levels to improve cell differentiation efficiency. Under the direction of Principal Investigator Domitilla Del Vecchio and Co-Investigators James J. Collins and Thorsten Schlaeger, the project focuses on creating genetic circuits that enhance the conversion of human induced pluripotent stem cells (hiPSCs) into hemogenic endothelial cells (HECs) and hematopoietic stem and progenitor cells (HSC/HPCs). The research addresses critical inefficiencies and variability in current differentiation protocols by engineering precise control of cell fate-specific transcription factors, with the objective of improving differentiation efficiency, consistency, and scalability for potential clinical translation of hiPSC-derived blood cell products. The project, scheduled for completion on January 31, 2029, will be performed at MIT's Cambridge, Massachusetts location and leverages expertise from MIT's Department of Mechanical Engineering, Department of Biological Engineering, Synthetic Biology Center, Broad Institute of MIT & Harvard, The Wyss Institute, and the Stem Cell Transplantation Program at Boston Children's Hospital. The anticipated deliverables include validated synthetic genetic circuits and methodologies that enable reproducible, high-efficiency conversion of stem cells into clinically viable hematopoietic cell products, addressing significant gaps in biomedical engineering technology for regenerative medicine and cell-based therapeutic applications.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $678.6k | 5/18/26 |