Project Grant K99HG014240
- This Project Grant award, funded by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) for $581,259, aims to develop a new platform for transcriptomic mapping of membraneless organelles (MLOs) and their internal subdomains. The University of Chicago, the awardee, will leverage an engineered reverse transcriptase to enable targeted in situ reverse transcription, providing a scalable method to characterize the transcriptomes of MLOs and understand how transcript...
- The project "Exploring Transcriptional Adaptation: Therapeutic Potential and Impact on Human Genetics" was awarded a $178,416 Project Grant by the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) on August 19, 2025. The project is being conducted by the Whitehead Institute for Biomedical Research, a non-profit research institute in Cambridge, Massachusetts. The primary objectives of the project are to: 1) Characterize the molecular features of...
- This federal Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) totaling $1,435,298 aims to develop new genomic and computational approaches to understand the functional impact of genetic variation in mRNA untranslated regions (UTRs) and its effects on protein output and gene function. The key objectives are to: 1) Identify and characterize variants in human 5' and 3' UTRs, and develop a high-throughput method to quantify the regulatory...
- The National Human Genome Research Institute (NHGRI) awarded a $435,406 Project Grant (CFDA 93.172 - Human Genome Research) to the University of Colorado-Denver to explore new strategies for inferring protein-level changes from mRNA abundance measurements. The 2-year project aims to develop conceptual embeddings of proteins that capture information on protein-protein interaction networks and protein sequence, domain, and structure. These embeddings will be evaluated for their utility in...
- The federal Project Grant award from the National Institutes of Health (NIH) Office of the Director under the Trans-NIH Research Support program (CFDA 93.310) provides $1,507,500 to the University of Massachusetts Medical School (UMass Medical) to expand the capabilities of third-generation DNA/RNA sequencing technologies. The project aims to generate rapid and cost-effective training libraries to allow for direct detection of common DNA damage and RNA modifications, enabling innovative...
- This $222,708 Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research at the Massachusetts Institute of Technology (MIT) to understand the mechanistic basis of individual and clustered enhancers in human cells. The goal is to investigate how enhancers, which are DNA regulatory sequences that determine gene expression patterns, can act across large genomic distances to regulate gene...
- This National Science Foundation (NSF) Biological Sciences program grant to Yale University, totaling $940,000 over 3 years beginning March 1, 2024, aims to systematically identify features of human and viral messenger RNAs (mRNAs) that regulate protein production. The project will employ a massively parallel reporter assay to quantify the impact of RNA modifications, structured RNA elements, and cell-specific factors on mRNA translation. Insights gained will provide a comprehensive...
- The National Science Foundation (NSF) awarded a $1,199,997 Project Grant under its Biological Sciences program (CFDA 47.074) to the University of Colorado-Denver. The grant will fund research to improve understanding of the mechanisms underlying messenger RNA (mRNA) localization and translation, and develop machine learning models to better predict protein production from mRNA. The project will apply recent advancements in RNA sequencing technology to study how factors like tRNA abundance and...
- The National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) awarded a $3,371,645 Project Grant to Boston Medical Center Corporation (BMC) to develop a comprehensive suite of computational tools to unlock the potential of spatial subcellular transcriptomics data. Specifically, the project will: Create a scalable and extensible database infrastructure to enable interactive analysis of large spatial transcriptomics datasets on standard computing systems. Develop novel methods...
- This federal Project Grant award from the National Science Foundation's Biological Sciences (CFDA 47.074) program provides $300,000.00 to the Massachusetts Institute of Technology (MIT) to develop advanced AI tools for investigating the 3D structure of the human genome and how it controls gene expression in different brain cell types. The project aims to create a detailed map of chromatin structure across brain cell types and provide computational models to explain how genetic information is...
This Project Grant award for $133,332.00, provided by the National Human Genome Research Institute (NHGRI) under the Human Genome Research program (CFDA 93.172), aims to develop a measurement system to characterize the kinetic parameters that control translation initiation for the entire human transcriptome. The project will adapt the recently developed MIT-Seq functional genomics platform from bacteria to human cells, allowing for quantitative measurement of ribosome binding and initiation rates across all mRNAs. This will enable researchers to better understand how translation initiation rates relate to protein expression levels, as well as the extent of alternative and small ORF translation in the human genome. The 5-year project will be conducted by the Massachusetts Institute of Technology (MIT), a leading private research university, with an expected completion date of July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $133.3k | 8/18/25 |