Project Grant R35GM159855
- This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
- This Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) supports research to improve the understanding of tissue-resident macrophage biology in vivo. The awardee, The Medical College of Wisconsin, Inc., will utilize a novel small vertebrate model, Danionella cerebrum, to systematically analyze the ontogeny, kinetics, and function of tissue-resident macrophages during homeostasis,...
- This $423,890 Project Grant was awarded on September 1, 2025 by the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859). The grant is being used to support fundamental scientific research and advanced training focused on understanding the mechanisms underlying the survival and uncontrolled proliferation of stem cells with DNA damage, and the influence of surrounding tissues on stem cell behavior during tissue...
- This Project Grant award, valued at $453,750.00 and awarded on August 8, 2025, supports research by The General Hospital Corporation (doing business as Massachusetts General Hospital) under the National Institute of General Medical Sciences' (NIGMS) Biomedical Research and Research Training program (CFDA 93.859). The research aims to explore how metabolic pathways control the transition between cell viability, pyroptosis (a lytic cell death program), and apoptosis (non-lytic cell death)....
- This federal Project Grant award of $388,000 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Northeastern University. The research aims to develop and validate a new class of engineered macrophages capable of tracking and modulating inflammation in vivo using multi-modal imaging techniques including ultrasound, MRI, and optical imaging. The project will establish a novel framework for...
- This $224,088 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research at Harvard University to study the developmental origins of adult pluripotent stem cells. The project aims to identify the molecular and cellular mechanisms that govern the specification and maintenance of adult pluripotent stem cell populations in highly regenerative species. Specifically, the...
- This $687,427 Project Grant awarded by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Federal Grant Program 93.865 - Child Health and Human Development Extramural Research, aims to investigate the role of macrophages in guiding digit regeneration. The project leverages a comparative mouse model of bone regeneration and scar formation to study a unique population of macrophages that associates with growing bone and expresses growth factors...
- This federal Project Grant award, valued at $453,750.00 and effective September 1, 2025, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The award supports a research program led by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to advance the understanding of perioperative neurocognitive disorders (PND) and their association with disruptions in...
- The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), received a $1,485,000 Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The award period runs from September 1, 2025 to August 31, 2028. The grant supports research focused on the discovery and characterization of programmable biological systems, particularly new RNA-guided functions found in...
- This $453,750 Project Grant award, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project led by The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the crosstalk between one-carbon metabolism, S-adenosyl-methionine (SAM) availability, and chromatin methylation. The project aims to provide innovative insights into how cells...
This Project Grant award of $412,500.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the role of macrophages in regulating stem and progenitor cell quality during development and regeneration. The research aims to dissect the molecular signals that mark stem/progenitor cells for macrophage interaction, compare regulatory cues delivered by macrophages in development versus regeneration across different tissue types, and uncover mechanisms leading to the elimination or expansion of specific stem cells. The project will utilize a technical approach combining molecular profiling, clonal analysis, live imaging, and zebrafish genetics to study macrophage-mediated stem cell quality assurance. The research will focus on the presentation of the 'eat me' signal calreticulin, which mediates macrophage-stem cell interactions in the blood, skeletal muscle, and spinal cord. The award has a project period from August 7, 2025 to June 30, 2030 and is being conducted by The General Hospital Corporation, doing business as Massachusetts General Hospital.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $412.5k | 8/6/25 |