Project Grant R01DK144486
- This $2,557,146 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was made to the Board of Regents of the Nevada System of Higher Education (UEI: WLDGTNCFFJZ3), operating through the University of Nevada, Reno, and will fund research to explore novel targets for gastrointestinal hormones and neuropeptides in the regulation of...
- This federal Project Grant award, totaling $2,334,824.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The overriding goal of this 4-year grant, awarded to The Johns Hopkins University, is to understand the pathogenesis of neonatal necrotizing enterocolitis (NEC) - a leading cause of death from gastrointestinal disease in premature infants - and to develop...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $708,138 to support the development of a biomechanocompatible small molecule-releasing scaffold for bladder augmentation. The goal is to create an alternative to conventional surgical approaches that use detubularized bowel tissue, which can have significant complications. The...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is focused on developing novel bioengineered regenerative medicine solutions based on vasculogenic regenerative medicine technology. The $543,826 award, granted on December 10, 2024, aims to investigate the mechanisms underlying in vivo vasculogenic reprogramming, specifically examining...
- The Beckman Research Institute of the City of Hope received a $140,116 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, awarded on September 15, 2025, will support research to identify and characterize a mechanism of communication between the intestine and white adipose tissue via intestinal mTOR signaling. The goal is to understand how...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), a component of the National Institutes of Health, awarded a $292,116 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Renovate Biosciences Inc. The grant aims to generate human livers from donor patient-specific cells using pigs as a "bio-incubator" for xenotransplantation, with the long-term goal of producing immune-compatible solid organs for...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $224,088 Project Grant to the Regents of the University of Michigan (University of Michigan) to conduct research aimed at elucidating the mechanisms of Notch signaling in immature and adult intestinal stem cells. The research will investigate how intestinal stem cells maintain Notch signaling and regulate stem cell...
- This federal Project Grant award of $2,390,830 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) aims to develop scalable and transplantable pancreatic islet organoids with engineered oxygenation. The 4-year project, awarded on September 1, 2025, will be carried out by the University of California, San Francisco. The research seeks to create an islet-supportive microenvironment to improve islet engraftment efficiency for Type 1 diabetes patients undergoing...
- This $2,970,076 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the developmental programming of adult intestinal stem cells (ISCs) and how an obesogenic maternal environment during pre- and postnatal development can establish a maladaptive pre-pathological ground state in offspring. Using genetically engineered mouse and organoid models, the...
- This $681,562 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate approaches for enhancing the metabolic maturity and functionality of human pluripotent stem cell-derived islet organoids, with the goal of improving their survival and efficacy for transplantation as a treatment for type 1 diabetes. The research will examine the use of pharmacological agents...
This $2,618,975 Project Grant was awarded on September 8, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports a 5-year research project led by the University of Texas Health Science Center at Houston to advance the development and functional capabilities of tissue-engineered intestine as a potential cure for pediatric intestinal failure. The research aims to identify the key biomechanical force-mediated processes required to generate a functional enteric nervous system within human intestinal organoid models, which is a critical unmet need for realizing the promise of regenerative intestinal tissue engineering.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.6m | 9/8/25 |