Project Grant R01DK143944
- This federal Project Grant award for $836,942 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research into the role of autophagy (self-digestion) in intestinal regeneration and stem cell activity. The research aims to investigate how autophagy contributes to injury resistance and the ability of certain intestinal cell types to re-acquire stem cell-like...
- This $108,486 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to identify novel immune markers associated with obesity-driven diseases. The objective is to utilize novel tools to study the inter-organ communication pathway between the intestine and adipose tissue immune cells. The research leverages a Cre-inducible...
- This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $734,612.00 to conduct research on the mechanisms through which stress and obesity reprogram monocyte and macrophage populations in response to elevated glucocorticoid levels. The research aims to elucidate how glucocorticoids induced by early-life stress and diet-induced...
- The National Cancer Institute (NCI) awarded a $621,570 Project Grant under the Cancer Cause and Prevention Research (CFDA 93.393) program to Arizona State University (ASU) on August 8, 2025. The grant supports research to determine the impact of maternal obesity on the transformative risk of colorectal cancer (CRC) in offspring by directly assessing the developmental programming of intestinal stem cells during pre- and postnatal growth. The research aims to investigate how naive exposure to an...
- This federal Project Grant award of $234,000 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the underlying mechanisms driving obesity and metabolic disorders in offspring of obese mothers. The research, conducted by Oregon Health & Science University, aims to leverage a mouse model to elucidate how maternal high-fat diet...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), totals $129,619 and will fund research on the interactions between the gut microbiome, intestinal development, and metabolic health in the context of fetal growth restriction (FGR). The overarching goal is to investigate how impaired intestinal and gut microbial development in FGR increases the...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $224,088 Project Grant to the Regents of the University of Michigan (University of Michigan) to conduct research aimed at elucidating the mechanisms of Notch signaling in immature and adult intestinal stem cells. The research will investigate how intestinal stem cells maintain Notch signaling and regulate stem cell...
- This $2,618,975 Project Grant was awarded on September 8, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The funding supports a 5-year research project led by the University of Texas Health Science Center at Houston to advance the development and functional capabilities of tissue-engineered intestine as a potential cure...
- This federal Project Grant award of $1,312,002.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to the University of Illinois to examine the mechanistic basis for transdifferentiation between type 3 innate lymphoid cells (ILC3s) and type 2 innate lymphoid cells (ILC2s), as well as the roles these plastic ILCs play in vivo. The 5-year project, which began...
- This $146,829 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the molecular mechanisms by which the bacterial protein BEFA (beta-cell expansion factor A) induces the proliferation and metabolic maturation of pancreatic beta cells. The research, conducted at the University of Oregon, utilizes single-cell imaging, genetic...
This $2,970,076 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) aims to investigate the developmental programming of adult intestinal stem cells (ISCs) and how an obesogenic maternal environment during pre- and postnatal development can establish a maladaptive pre-pathological ground state in offspring. Using genetically engineered mouse and organoid models, the project will characterize ISC changes in offspring exposed to a maternal high-fat western diet, and test the duration of these features as the offspring age, including upon reintroduction of the diet. This research seeks to advance the understanding of how early life environmental exposures influence intestinal homeostasis and long-term disease risk. The award was made to Arizona State University, a prominent research institution, and has an ultimate completion date of September 14, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 9/11/25 |