This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,108,154 to develop a stem cell-based multi-cellular platform that integrates diverse types of immune cells with stem cell-derived islets. The goal is to create an improved preclinical research model to accelerate the development of therapeutic interventions for Type 1...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $208,428 to The Regents of the University of California, San Francisco (UCSF) to enhance the safety and efficacy of stem cell-derived islet transplantation for treating type 1 diabetes. The key focus is on utilizing CRISPR-mediated genome engineering to improve islet cell engraftment,...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) provides $174,368 to the Regents of the University of Michigan to support a research project focused on understanding the role of the LRRK2 kinase in pancreatic beta cell responses to inflammatory damage. The goal is to gain insights into the molecular mechanisms that govern beta cell survival under inflammatory conditions, which could inform new therapeutic approaches for treating...
This Project Grant award of $199,258 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to The Leland Stanford Junior University will fund research to develop reduced-intensity conditioning regimens to induce sustained mixed hematopoietic chimerism and tolerance for islet cell transplantation in type 1 diabetes. The research aims to 1) optimize a low-intensity conditioning protocol to reduce the radiation dose required for generating mixed chimerism, and 2)...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $108,000 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Michigan. The grant, titled "MICHIGAN SUMMER UNDERGRADUATE RESEARCH EXPERIENCE: DIABETES & METABOLIC DISEASES", will provide a 5-year summer research experience for 14 undergraduate students per year to instill an appreciation and passion for...
This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a systems biology research project conducted by the Regents of the University of Michigan. The key objectives are to: 1) Validate predicted transcription factor binding motifs related to the hypoxia-inducible factor 1-alpha (HIF1A) in areas of open chromatin using multiomics data, and 2)...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,208,620.00 to the University of Massachusetts Medical School to develop humanized mouse models to study the interaction between human immune systems and autologous human islets derived from induced pluripotent stem cells. The goal is to increase understanding of the dynamic...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $436,277 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of Delaware. The grant titled "NEPHROGENESIS ON A CHIP: AN SIMPLE MODULAR PLATFORM TO SPATIALLY PATTERN EXTRACELLULAR MATRIX, STROMAL CELLS, AND SOLUBLE FACTORS" aims to develop an easy-to-use 3D in vitro model of the developing nephron that allows spatial patterning...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $298,364 in funding to Immunoshield Therapeutics Inc. to investigate optimal islet density and dosage within macroencapsulation devices for clinical islet transplantation to treat type 1 diabetes. The research aims to address limitations in current macroencapsulation approaches, such as...
This Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,201,988 to Yale University to develop advanced pancreatic-immune organoid models for studying type 1 diabetes (T1D) subtypes and therapeutic responses. The goal is to identify B cell intrinsic features that determine T1D progression and responses to therapies. In Phase 1, the...