Project Grant R01DK144096
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $726,922 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Beckman Research Institute of the City of Hope. The grant will fund research examining the role of chromatin remodeling factors, specifically the protein JARID2, in modulating inflammatory processes that contribute to diabetic microvascular complications such as retinopathy and...
- This $596,345 federal Project Grant was awarded on May 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Augusta University Research Institute, Inc. in Augusta, GA to investigate the molecular mechanisms underlying diabetic renal hypertrophy and its impact on acute kidney injury (AKI) susceptibility in diabetic...
- This $2,782,476 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports research to determine the molecular mechanisms underlying pancreatic beta cell response to metabolic stress, a key factor in the development of type 2 diabetes. The 4-year project aims to leverage in vitro human beta cell models, single-cell transcriptomic analyses, and targeted drug screening to delineate the dynamic chromatin and transcriptomic changes that...
- This federal Project Grant award of $1,620,238 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will fund a research project at the University of North Carolina at Chapel Hill (UNC-CH) to detect regulatory variants and elements at type 2 diabetes genetic association signals across multiple tissues, including pancreatic islets, adipose, skeletal...
- The federal Project Grant award of $535,556.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Alabama at Birmingham (UAB). The funding will support a research project to investigate the role of a novel histone modification, H3T32 O-GlcNAc, in endothelial cell dysfunction and atherosclerosis. The 5-year project aims to elucidate the epigenetic features of this histone modification under...
- This Project Grant award of $248,915 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to unravel the role of epigenetics and cytokines in type 2 diabetes among African-ancestry populations in the U.S. and Europe. The research aims to identify causal associations between DNA methylation, circulating cytokines, and diabetes risk in these populations...
- This federal Project Grant award of $641,794 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the mechanisms that protect beta-cells from DNA damage during periods of growth and adaptation, in order to maintain beta-cell homeostasis and prevent the loss of functional beta-cells, a key factor in the development of type 1 and type 2...
- This federal Project Grant award in the amount of $1,428,186.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Massachusetts. The project aims to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans, which has implications for understanding the early...
- This Project Grant award of $830,500.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research investigating the role of glycosphingolipids in kidney disease associated with diabetes and obesity. The key objectives are to: Test whether inhibiting glucosylceramide synthesis in podocytes, renal tubules, or the immune system can prevent progression of kidney disease in mouse...
- This $451,000 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research to investigate the role of microRNAs in adipose tissue from people with HIV who develop type 2 diabetes. The project aims to evaluate microRNA expression in adipose tissue and explore whether circulating microRNAs in plasma could serve as biomarkers of risk...
This $2,381,683 federal Project Grant was awarded on September 7, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by the University of Alabama at Birmingham (UAB) to investigate the role of histone H3 O-GlcNAcylation in endothelial cells and its contribution to diabetes-accelerated atherosclerosis. Specifically, the research aims to 1) examine the effects of endothelial cell OGT and H3T32 O-GlcNAc on diabetes-accelerated atherosclerosis in mouse models, and 2) define the epigenetic mechanisms by which H3T32 O-GlcNAc regulates the expression of atheroprotective genes in endothelial cells. The research seeks to provide mechanistic insights into how diabetes-induced histone modifications impact vascular function and the development of diabetic cardiovascular complications.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.4m | 9/5/25 |