Project Grant R01HL178662
- This $2,381,683 federal Project Grant was awarded on September 7, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by the University of Alabama at Birmingham (UAB) to investigate the role of histone H3 O-GlcNAcylation in endothelial cells and its contribution to diabetes-accelerated atherosclerosis. Specifically, the research aims to 1)...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research on the role of heterochromatin dynamics in the plasticity of vascular smooth muscle cells (SMCs). The $756,224 grant, awarded to Yale University on August 15, 2025, will fund investigations into how epigenetic regulation of heterochromatin, particularly through the histone methyltransferase SUV39H1, influences SMC phenotypic transitions. The...
- This federal Project Grant award, valued at $162,703.00 and granted by the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research), aims to determine whether streamlined, standardized blood pressure (BP) measurement protocols can be implemented in primary care settings. The project builds on the Alabama Cardiovascular Cooperative's Heart Health Improvement Project and seeks to improve the accuracy and efficiency of BP measurements to inform treatment decisions...
- The University of Alabama at Birmingham (UAB) received a $637,732 project grant from the National Heart, Lung, and Blood Institute's Cardiovascular Diseases Research program (CFDA 93.837) to conduct research on improving the cardiac microenvironment as a novel strategy against diabetic ischemic heart failure. The project aims to leverage insights from cellular secretome research to transform treatment strategies for diabetic ischemic heart failure. Specifically, the research will investigate how...
- This Project Grant award, valued at $249,000.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program. The grant supports a research project at the University of Alabama at Birmingham (UAB) titled "Early Life Stress and Cardiovascular Disease Risk: Identifying the Role of Microbial Metabolites." The project aims to investigate how early life stress affects the gut microbiome and related...
- This federal Project Grant award of $1,119,410.00 was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant supports a multi-disciplinary research initiative to investigate longitudinal changes in DNA methylation (LC-DNAM) and its relationship to cardiovascular disease (CVD) risk factors and outcomes across four large population-based cohort studies - ARIC, CARDIA, FHS, and MESA. The research aims to: 1)...
- This federal Project Grant award of $248,955 from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by Howard University to characterize the roles of bivalent chromatin domains in regulating CD4+ T cell differentiation and plasticity. The award will enable the principal investigator to expand their biological skills and apply a novel single-cell epigenetic profiling technique (iSCCHIC-seq) to study how bivalent domains regulate...
- This federal Project Grant award of $701,791 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to investigate the role of neddylation, a post-translational modification, in protecting endothelial cell integrity and function. The research aims to establish the pathophysiological significance of neddylation in the endothelium and identify key downstream effectors. The University of Nebraska, Lincoln is the awardee and will utilize...
- The federal Project Grant award of $678,803.00 was provided by the National Heart, Lung, and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to The Ohio State University. The funding supports research to investigate the role of the mitochondrial deubiquitinase USP30 in regulating microvascular endothelial cell function and its potential as a therapeutic target for acute inflammatory diseases like acute respiratory distress syndrome (ARDS) and sepsis. Key...
- This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to support research on modulating the resolution of angiogenesis and normalizing the vasculature for therapeutic benefit in cardiovascular diseases. The $549,665 award, effective January 15, 2025 through November 30, 2028, will fund research conducted by the University of Maryland, Baltimore to investigate mechanisms that regulate the resolution of angiogenesis,...
The federal Project Grant award of $535,556.00 was provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Alabama at Birmingham (UAB). The funding will support a research project to investigate the role of a novel histone modification, H3T32 O-GlcNAc, in endothelial cell dysfunction and atherosclerosis. The 5-year project aims to elucidate the epigenetic features of this histone modification under atheroprone shear stress conditions, determine its impact on chromatin accessibility and atheroprotective gene expression, and evaluate its functional role in atherosclerosis using a mouse model. The award commences on August 1, 2025 and is expected to be completed by May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $535.6k | 8/1/25 |